Assessment of dietary nitrate intake in humans: a systematic review
Babateen AM, Fornelli G, Donini LM, Mathers JC, Siervo M
The American journal of clinical nutrition · 52 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (MR/N007921/1); Medical Research Council (MR/N007921/1)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-05-22 · Am J Clin Nutr · vol. 108 · número 4 · págs. 878–888
- Editorial
- Elsevier BV
- Citado
- 72 citas · más que el 73% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 94 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Sodium Intake and Health · Food and Agricultural Sciences
- Palabras clave
- dietary nitrate intake, nitrate, food composition tables, dietary assessment, food frequency questionnaire, cancer risk, cardiometabolic disease, economic development, gross domestic product, globalization index
- MeSH
- humans, cardiovascular diseases, nitrates, diet, diet surveys, nutrition assessment, feeding behavior, energy intake, internationality, gross domestic product, recommended dietary allowances
5 autores
- Abrar M. Babateen🇸🇦🇬🇧 · autor de correspondenciaUmm al-Qura University; Newcastle University
- Gianfranco Fornelli🇮🇹🇬🇧Vita-Salute San Raffaele University; Newcastle University
- Lorenzo M. Donini🇮🇹Sapienza University of Rome
- John Cummings Mathers🇬🇧Newcastle University
- Mario Siervo🇬🇧Newcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The nitrate content of foods and water is highly variable, which has implications for the compilation of food-composition databases and assessment of dietary nitrate intake.
Objective
A systematic review was conducted to ascertain the dietary assessment methods used and to provide estimates of daily nitrate intake in humans.
Design
Relevant articles were identified by a systematic search of 3 electronic databases (PubMed, Web of Science, and Embase) from inception until February 2018. Observational studies conducted in adult populations and reporting information on dietary assessment methods and daily nitrate intake were included. Ecological analyses were conducted to explore the association of nitrate intake with indexes of economic development [Gross Domestic Product (GDP) and KOF Index of Globalization].
Results
A total of 55 articles were included. Forty-two studies investigated associations between nitrate intake and disease risk; 36 (87%) of these studies examined the association between nitrate intake and cancer risk, whereas only 6 studies explored the association of nitrate intake with the risk of diabetes, glaucoma, kidney failure, hypertension, and atherosclerotic vascular disease. The majority of studies used food-frequency questionnaires to assess nitrate intake (n = 43). The median daily nitrate intakes in healthy and patient populations were 108 and 110 mg/d, respectively. We found a significant inverse correlation of nitrate intake with GDP (r = -0.46, P < 0.001) and KOF index (r = -0.31, P = 0.002).
Conclusions
The median estimated daily nitrate intakes by healthy and patient populations were similar, and these values were below the safe upper intake of daily intake (3.7 mg nitrate ion/kg body weight). However, there is considerable heterogeneity in the application of food-composition tables, which may have implications for the accuracy of estimated daily nitrate intake. The association between nitrate intake and risk of cardiometabolic diseases needs further investigation. The protocol for this systematic review has been registered in the PROSPERO database (https://www.crd.york.ac.uk/prospero; CRD number: 42017060354).
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