β-Cryptoxanthin and zeaxanthin are highly bioavailable from whole-grain and refined biofortified orange maize in humans with optimal vitamin A status: a randomized, crossover, placebo-controlled trial
Titcomb TJ, Sheftel J, Sowa M, Gannon BM, Davis CR, Palacios-Rojas N, Tanumihardjo SA
The American journal of clinical nutrition · 8 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Bill and Melinda Gates Foundation
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- Bill and Melinda Gates Foundation (OPP27510); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007665)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-10-01 · Am J Clin Nutr · vol. 108 · número 4 · págs. 793–802
- Editorial
- Elsevier BV
- Citado
- 21 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Plant Micronutrient Interactions and Effects · Antioxidant Activity and Oxidative Stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- beta-cryptoxanthin, zeaxanthin, biofortified maize, orange maize, carotenoid bioavailability, vitamin A status, serum retinol, xanthophylls, vitamin A deficiency, carotenoid absorption
- MeSH
- liver, humans, zea mays, vitamin a deficiency, carbon isotopes, beta carotene, vitamin a, diet, cross-over studies, feeding behavior, biological availability, nutritional status, bread, food, fortified, adult, africa, female, male, young adult, zeaxanthins, biomarkers, whole grains, beta-cryptoxanthin, provitamins
7 autores
- Tyler J. Titcomb🇺🇸University of Wisconsin–Madison
- Jesse Sheftel🇺🇸University of Wisconsin–Madison
- Margaret Sowa🇺🇸University of Wisconsin–Madison
- Bryan M Gannon🇺🇸University of Wisconsin–Madison
- Christopher R. Davis🇺🇸University of Wisconsin–Madison
- Natalia Palacios‐Rojas🇲🇽Centro Internacional de Mejoramiento de Maíz Y Trigo
- Sherry Ann Tanumihardjo🇺🇸 · autor de correspondenciaUniversity of Wisconsin–Madison
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Biofortification of staple crops with β-carotene is a strategy to reduce vitamin A deficiency, and several varieties are available in some African countries. β-Cryptoxanthin (BCX)-enhanced maize is currently in field trials. To our knowledge, maize BCX bioavailability has not been assessed in humans. Serum retinol 13C content and xanthophyll concentrations are proposed effectiveness biomarkers for biofortified maize adoption.
Objective
We determined the relative difference in BCX and zeaxanthin bioavailability from whole-grain and refined BCX-biofortified maize during chronic feeding compared with white maize and evaluated short-term changes in 13C-abundance in serum retinol.
Design
After a 7-d washout, 9 adults (mean ± SD age: 23.4 ± 2.3 y; 5 men) were provided with muffins made from BCX-enhanced whole-grain orange maize (WGOM), refined orange maize (ROM), or refined white maize (RWM) for 12 d in a randomized, blinded, crossover study followed by a 7-d washout. Blood was drawn on days 0, 3, 6, 9, 12, 15, and 19. Carotenoid areas under the curve (AUCs) were compared by using a fixed-effects model. 13C-Abundance in serum retinol was determined by using gas chromatography/combustion/isotope-ratio mass spectrometry on days 0, 12, and 19. Vitamin A status was determined by 13C-retinol isotope dilution postintervention.
Results
The serum BCX AUC was significantly higher for WGOM (1.70 ± 0.63 μmol ⋅ L-1 ⋅ d) and ROM (1.66 ± 1.08 μmol ⋅ L-1 ⋅ d) than for RWM (-0.06 ± 0.13 μmol ⋅ L-1 ⋅ d; P < 0.003). A greater increase occurred in serum BCX from WGOM muffins (131%) than from ROM muffins (108%) (P ≤ 0.003). Zeaxanthin AUCs were higher for WGOM (0.94 ± 0.33) and ROM (0.96 ± 0.47) than for RWM (0.05 ± 0.12 μmol ⋅ L-1 ⋅ d; P < 0.003). The intervention did not affect predose serum retinol 13C-abundance. Vitamin A status was within an optimal range (defined as 0.1-0.7 μmol/g liver).
Conclusions
BCX and zeaxanthin were highly bioavailable from BCX-biofortified maize. The adoption of BCX maize could positively affect consumers' BCX and zeaxanthin intakes and associated health benefits. This trial is registered at www.clinicaltrials.gov as NCT02800408.
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