Vitamin D and the gut microbiome: a systematic review of in vivo studies
Waterhouse M, Hope B, Krause L, Morrison M, Protani MM, Zakrzewski M, Neale RE
European journal of nutrition · 148 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
- Gobierno
- National Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-10-15 · Eur J Nutr · vol. 58 · número 7 · págs. 2895–2910
- Editorial
- Springer Science+Business Media
- Citado
- 183 citas · más que el 83% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Vitamin D Research Studies · Oral microbiology and periodontitis research
- Palabras clave
- vitamin D, gut microbiota, Bacteroidetes, vitamin D receptor, CYP27B1, vitamin D deficiency, diet, immune regulation, host-microbe interactions
- MeSH
- animals, humans, mice, vitamins, vitamin d, diet, models, animal, gastrointestinal microbiome
7 autores
- Mary A. Waterhouse🇦🇺QIMR Berghofer Medical Research Institute
- Bronwyn Hope🇦🇺QIMR Berghofer Medical Research Institute
- Lutz Krause🇦🇺The University of Queensland
- Mark D. Morrison🇦🇺The University of Queensland
- Melinda M. Protani🇦🇺The University of Queensland
- Martha Zakrzewski🇦🇺QIMR Berghofer Medical Research Institute
- Rachel Ε. Neale🇦🇺 · autor de correspondenciaQIMR Berghofer Medical Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Variation in the human microbiome has been linked with a variety of physiological functions, including immune regulation and metabolism and biosynthesis of vitamins, hormones, and neurotransmitters. Evidence for extraskeletal effects of vitamin D has been accruing and it has been suggested that the effect of vitamin D on health is partially mediated through the microbiome. We aimed to critically evaluate the evidence linking vitamin D and the gastrointestinal microbiome.
Methods
We systematically searched the Embase, Web of Science, PubMed and CINAHL databases, including peer-reviewed publications that reported an association between a measure of vitamin D and the gastrointestinal microbiome in humans or experimental animals.
Results
We included 10 mouse and 14 human studies. Mouse studies compared mice fed diets containing different levels of vitamin D (usually high versus low), or vitamin D receptor knockout or Cyp27B1 knockout with wild-type mice. Five mouse studies reported an increase in Bacteroidetes (or taxa within that phylum) in the low vitamin D diet or gene knockout group. Human studies were predominantly observational; all but two of the included studies found some association between vitamin D and the gut microbiome, but the nature of differences observed varied across studies.
Conclusions
Despite substantial heterogeneity, we found evidence to support the hypothesis that vitamin D influences the composition of the gastrointestinal microbiome. However, the research is limited, having been conducted either in mice or in mostly small, selected human populations. Future research in larger population-based studies is needed to fully understand the extent to which vitamin D modulates the microbiome.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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