Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 Pathway
Fu J, Soroka DN, Zhu Y, Sang S
Journal of agricultural and food chemistry · 22 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Food and Agriculture
- Subvenciones
- National Institute of Food and Agriculture (2012-38821-20012)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-10-24 · J Agric Food Chem · vol. 66 · número 45 · págs. 11935–11942
- Editorial
- American Chemical Society
- Citado
- 33 citas · más que el 82% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cancer-related Molecular Pathways · Cancer, Lipids, and Metabolism · Cancer, Hypoxia, and Metabolism
- Palabras clave
- Apoptosis, Downregulation and upregulation, Colorectal cancer, Cancer research, Cell cycle, Cell cycle checkpoint, Cancer, Programmed cell death, Mdm2, Cell biology, Cancer cell, Chemistry, Puma, Signal transduction, Biology, Biochemistry, Genetics
- MeSH
- cell line, tumor, mitochondria, humans, colonic neoplasms, resorcinols, plant extracts, antineoplastic agents, apoptosis, tumor suppressor protein p53, cyclin-dependent kinase inhibitor p21, proto-oncogene proteins c-mdm2, proteolysis, cell cycle checkpoints, whole grains
4 autores
- Junsheng Fu🇺🇸🇨🇳North Carolina Agricultural and Technical State University; Fujian Agriculture and Forestry University
- Dominique N. Soroka🇺🇸North Carolina Agricultural and Technical State University
- Yingdong Zhu🇺🇸North Carolina Agricultural and Technical State University
- Shengmin Sang🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill; North Carolina Agricultural and Technical State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Colon cancer, one of the leading causes of cancer-associated deaths, is the target of choice for nutrition-based-prevention approaches because of the direct and early contact between the active compounds and the cancerous tissues. We previously reported alkylresorcinols (ARs) as the major active components in wheat bran against human colon cancer. Here, we further investigate the anticancer mechanisms of action of ARs. Our mechanistic studies indicated that AR C15 and AR C17 exert their anticancer activities in colon-cancer cells by inducing apoptosis through PUMA upregulation and mitochondrial-pathway activation, inducing cell-cycle arrest through p21 upregulation, and inhibiting proteasome activity and Mdm2 expression. This cascade of distinct mechanisms was linked to the consequent activation and accumulation of p53. The results of treatment with p53 inhibitor further confirmed that the p53 pathway might play a very important role in AR-induced apoptosis in colon-cancer cells. Altogether these results show that AR C15 and AR C17 can specifically activate the mitochondrial pathway of apoptosis and cause cell-cycle arrest and that inhibition of p53 greatly reduces the activation of this pathway.
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