Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Disease
Yu C, Xue H, Wang L, Chen Q, Chen X, Zhang Y, Hu G, Ling W
Circulation research · 61 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-09-28 · Circ Res · vol. 123 · número 8 · págs. 996–1007
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 82 citas · más que el 98% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Bone health and osteoporosis research
- Palabras clave
- Medicine, Coronary artery disease, Internal medicine, Vitamin D and neurology, Hazard ratio, Cohort, Quartile, Bioavailability, Proportional hazards model, Gastroenterology, Endocrinology, Cardiology, Confidence interval, Pharmacology
- MeSH
- humans, vitamin d deficiency, vitamin d, coronary angiography, enzyme-linked immunosorbent assay, prognosis, cause of death, risk assessment, risk factors, prospective studies, time factors, adult, aged, aged, 80 and over, middle aged, female, male, coronary artery disease, biomarkers
8 autores
- Chao Yu🇨🇳 · autor de correspondenciaKey Laboratory of Guangdong Province
- Hongliang Xue · autor de correspondencia
- Liqing Wang🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Qian Chen
- Xuechen Chen
- Yuan Zhang🇨🇳General Hospital of Guangzhou Military Command
- Gang Hu🇺🇸Pennington Biomedical Research Center
- Wenhua Ling🇨🇳Key Laboratory of Guangdong Province
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Bioavailable and free 25-hydroxyvitamin D (25(OH)D) are emerging measurements of vitamin D. Whether serum bioavailable or free 25(OH)D level is associated with mortality in patients with coronary artery disease (CAD) is unknown.
Objective
Our aim is to determine the potential association between serum total, bioavailable, and free 25(OH)D levels and the risk of mortality among patients with CAD.
Methods and results
We measured serum 25(OH) levels in 1387 patients with angiographically confirmed CAD from the Guangdong Coronary Artery Disease Cohort. Serum DBP (vitamin D-binding protein) levels were measured using a polyclonal immunoassay, and serum-free 25(OH)D levels were measured using a 2-step immunoassay. Bioavailable 25(OH)D levels were calculated using a previously validated formula. By the median follow-up time of 6.7 years, 205 patients had died, including 134 deaths from cardiovascular diseases. In multivariate analyses, low serum bioavailable 25(OH)D level was significantly associated with increased risks of mortality, independent of established cardiovascular risk factors, features and treatments of CAD, factors associated with vitamin D and mineral metabolism, and CRP (C-reactive protein). The multivariable-adjusted hazard ratios across quartiles of bioavailable 25(OH)D were 1.79, 1.35, 1.36, and 1.00 for all-cause mortality ( P for trend=0.01) and 2.58, 1.85, 1.73, and 1.00 for cardiovascular mortality ( P for trend=0.001), respectively. Serum-free 25(OH)D level was inversely associated with the risk of mortality, with the extreme-quartile hazard ratios of 1.64 for all-cause mortality ( P for trend=0.024) and 1.97 for cardiovascular mortality ( P for trend=0.013). In contrast, serum total 25(OH)D level was not significantly associated with all-cause mortality or cardiovascular mortality.
Conclusions
Lower serum bioavailable and free 25(OH)D levels rather than total 25(OH)D level are independently associated with an increased risk of all-cause mortality and cardiovascular mortality in a population-based CAD cohort.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.