Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized trials
Xu Y, Wan Q, Feng J, Du L, Li K, Zhou Y
Medicine · 43 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (30901427)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-10-01 · Medicine (Baltimore) · vol. 97 · número 43 · pág. e12995
- Editorial
- Wolters Kluwer
- Citado
- 54 citas · más que el 91% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Palabras clave
- Medicine, Meta-analysis, Strictly standardized mean difference, Confidence interval, Cochrane Library, Observational study, Internal medicine, Randomized controlled trial, Subgroup analysis, Whole grains, Systemic inflammation, C-reactive protein, MEDLINE, Gastroenterology, Inflammation, Food science
- MeSH
- humans, inflammation, diet, randomized controlled trials as topic, whole grains
6 autores
- Yujie Xu
- Qianyi Wan
- Jinhua Feng🇨🇳Sichuan University; West China Hospital of Sichuan University
- Liang Du🇬🇧Cochrane
- Ka Li🇨🇳 · autor de correspondenciaSichuan University; West China Hospital of Sichuan University
- Yong Hong Zhou · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Backgrounds
Observational studies had suggested an inverse association between whole grain consumption and concentration of inflammatory markers, but evidence from interventional studies was inconsistent. Therefore, we conducted a meta-analysis of randomized trials to have a better understanding of this issue.
Methods
This study has been registered in PROSPERO (ID: CRD42018096533). We searched PubMed, Web of Science, Embase, Medline, and Cochrane Library for articles focusing on the topic from inception to 1 January, 2018. Summary standardized mean difference (SMD) and 95% confidence interval (CI) were calculated by using either random effect model or fixed effect model according to the heterogeneity of included studies. Subgroup analysis was also performed.
Results
Totally 9 randomized trials included 838 participants were identified. In a pooled analysis of all studies, consumption of whole grains had an inverse association with inflammatory markers (SMD 0.16, 95% CI, 0.02-0.30), including C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β). Specific analyses for CRP and IL-6 yielded that whole grain diet was related with a significant decrease in the concentration of CRP (SMD 0.29, 95% CI, 0.08-0.50) and IL-6 (SMD 0.19, 95% CI, 0.03-0.36).
Conclusions
The evidence suggested that citizens could benefit from increased whole grain intake for reducing systemic inflammation. Further well-designed studies are required to investigate the mechanism under the appearance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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