Financiado en parte por International Nut and Dried Fruit Council
Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial
Salas-Huetos A, Moraleda R, Giardina S, Anton E, Blanco J, Salas-Salvadó J, Bulló M
The American journal of clinical nutrition · 71 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- International Nut and Dried Fruit Council
- Subvenciones
- International Nut and Dried Fruit Council (PV15110S)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-10-25 · Am J Clin Nutr · vol. 108 · número 5 · págs. 953–962
- Editorial
- Elsevier BV
- Citado
- 79 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Sperm and Testicular Function · Nuts composition and effects · Nutritional Studies and Diet
- Palabras clave
- nut consumption, semen quality, Western diet, sperm count, sperm motility, sperm morphology, sperm DNA fragmentation, microRNA, omega-3 fatty acids, dietary intervention, male fertility, sperm DNA methylation, reactive oxygen species, healthy men, dietary fat intake
- MeSH
- spermatozoa, chromosomes, semen, humans, nuts, reactive oxygen species, dietary fats, fatty acids, omega-3, micrornas, sperm count, diet, feeding behavior, dna fragmentation, sperm motility, dna methylation, diet, mediterranean, nutritive value, reference values, adolescent, adult, male, semen analysis, young adult, diet, western
7 autores
- Albert Salas‐Huetos🇪🇸Instituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Rocío Moraleda🇪🇸Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Simona Giardina🇪🇸Instituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Ester Antón🇪🇸Universitat Autònoma de Barcelona
- Joan Blanco🇪🇸Universitat Autònoma de Barcelona
- Jordi Salas‐Salvadó🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Mònica Bulló🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Human semen quality has declined in industrialized countries. Pollution, smoking, and the consumption of a Western-style diet are all hypothesized as potential causes.
Objective
We evaluated the effect of chronic consumption of nuts on changes in conventional semen parameters and the potential mechanisms implicated.
Design
The FERTINUTS study was a 14-wk randomized, controlled, parallel trial. A total of 119 healthy men, aged 18-35 y, were allocated to 1 of 2 intervention groups: one group was fed the usual Western-style diet enriched with 60 g of a mixture of nuts/d (nut group), and the other was fed the usual Western-style diet avoiding nuts (control group). Semen and blood samples were collected at baseline and at the end of the intervention. Dietary information was recorded throughout the trial. Changes in conventional semen parameters (pH, volume, sperm count and concentration, motility, and morphology) were determined as primary outcomes. The effect of nut consumption on sperm DNA fragmentation (SDF), reactive oxygen species (ROS) production, chromosome anomalies (X, Y, and 18), total DNA methylation, and microRNA expression were measured in sperm samples as potential causes of the changes in the seminogram.
Results
Compared with the control group, improvements in total sperm count (P = 0.002) and vitality (P = 0.003), total motility (P = 0.006), progressive motility (P = 0.036), and morphology of sperm (P = 0.008) were observed in the nut group. Participants in the nut group showed an increase in the consumption of total fat, monounsaturated fatty acids, polyunsaturated fatty acids, magnesium, vitamin E, α-linolenic acid, total omega-3 (n-3) and ω-3:ω-6 ratio intake during the intervention. Participants in the nut group showed a significant reduction in SDF (P < 0.001) and in the expression of hsa-miR-34b-3p (P = 0.036). No significant changes in ROS, sperm chromosome anomalies, or DNA methylation were observed between groups.
Conclusions
The inclusion of nuts in a Western-style diet significantly improves the total sperm count and the vitality, motility, and morphology of the sperm. These findings could be partly explained by a reduction in the sperm DNA fragmentation. This trial was registered at ISRCTN as ISRCTN12857940.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.