The association between blood concentration of 25- hydroxyvitamin D and sarcopenia: a meta-analysis
Luo J, Quan Z, Lin S, Cui L
Asia Pacific journal of clinical nutrition · 26 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-09-16 · Asia Pac J Clin Nutr · vol. 27 · número 6 · págs. 1258–1270
- Editorial
- National Institutes of Health
- Citado
- 36 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition, Genetics, and Disease · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Sarcopenia, Medicine, Confidence interval, Internal medicine, Prospective cohort study, Meta-analysis, Cohort study, Confounding, Subgroup analysis, Gastroenterology
- MeSH
- humans, vitamin d, sensitivity and specificity, case-control studies, prospective studies, cross-sectional studies, aged, aged, 80 and over, middle aged, female, male, sarcopenia, observational studies as topic
4 autores
- Jing Luo🇨🇳Qingdao University
- Zhenyu Quan🇨🇳Yanbian University
- Song Lin🇨🇳Qingdao University
- Lianhua Cui🇨🇳Qingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Associations between blood 25-hydroxyvitamin D (25(OH)D) concentration and sarcopenia remain controversial; thus, this meta-analysis was conducted to explore the relationship between blood 25(OH)D concentration and sarcopenia.
Design
We searched the PubMed and EMBASE databases for relevant published observational studies that investigated blood 25(OH)D concentration and sarcopenia up to June 2017.We then investigated data from these studies that compared blood 25(OH)D concentrations between the sarcopenia and healthy control groups. A random-effect model was used to calculate the pooled weighted mean difference (WMD) of blood 25(OH)D concentration with a 95% confidence interval (95% CI).
Results
Twelve studies (eight cross-sectional, two matched case-control, and two prospective cohort studies) with a total of 22,590 individuals were included. Sarcopenic individuals had lower blood 25(OH)D concentrations than healthy controls (WMD=-2.14, 95% CI: -2.81--1.48; I2=74.6%). Subgroup analysis showed that the methods of assessing both blood 25(OH)D concentrations and sarcopenia might be sources of heterogeneity, and further showed that studies excluding obese individuals and different sarcopenia assessment criteria enhanced the relationship. Sensitivity analysis by one-study-removed confirmed the robustness of these results.
Conclusions
Our study shows that sarcopenic adults have lower blood 25(OH)D concentrations. Further high-quality large-scale prospective cohort studies are needed to confirm these findings.
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