Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk
Kim NH, Seol JE, Kim J, Lee BH, Hwang DY, Jeong J, Lee HJ, Ahn YO, Kim DH, Lee JE
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 8 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciación no declaradaMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-11-26 · Eur J Cancer Prev · vol. 28 · número 4 · págs. 304–310
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 10 citas · más que el 54% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Peroxisome Proliferator-Activated Receptors · Cancer, Lipids, and Metabolism · Metabolomics and Mass Spectrometry Studies
- Palabras clave
- Odds ratio, Internal medicine, Red meat, Allele, Medicine, Colorectal cancer, CYP2E1, Logistic regression, Gastroenterology, Case-control study, Genotype, Biology, Endocrinology, Oncology, Genetics, Cancer, Metabolism, Pathology, Cytochrome P450, Gene
- MeSH
- humans, colorectal neoplasms, genetic predisposition to disease, cytochrome p-450 cyp2e1, ppar gamma, diet surveys, risk factors, case-control studies, polymorphism, single nucleotide, adult, aged, middle aged, female, male, republic of korea, red meat
10 autores
- Na-Hui Kim🇰🇷🇳🇱Sookmyung Women's University; Food & Nutrition
- Ju Eun Seol🇰🇷🇳🇱Sookmyung Women's University; Food & Nutrition
- Jeongseon Kim🇺🇸National Cancer Center
- Bong-Hwa Lee🇰🇷 · autor de correspondenciaHallym University
- Dae–Yong Hwang🇰🇷Konkuk University Medical Center
- Jinyoung Jeong🇰🇷Hallym University
- Hun Jae Lee🇰🇷 · autor de correspondenciaInha University
- Yoon‐Ok Ahn🇰🇷Seoul National University
- Donghyun Kim🇰🇷Hallym University
- Jung Eun Lee🇰🇷🇳🇱 · autor de correspondenciaSeoul National University; Food & Nutrition
Resumen
El texto original del estudio, en el idioma en que se publicó.
The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case-control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire. Polymorphisms of CYP2E1 (rs3813867) and PPARγ (rs1801282 or rs3856806) were identified using the TaqMan assay. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression models. We found that the association between red meat and CRC varied by CYP2E1 polymorphisms; ORs (95% CIs) for at least five or more vs. less than one time/week of red meat intake were 2.77 (1.23-6.25) among individuals with C alleles of CYP2E1 and 0.89 (0.51-1.54) among individuals with the GG allele (Pinteraction=0.05). Compared with those individuals with the CC allele, increasing risk of CRC with increasing red meat intake was more pronounced among individuals with T alleles of PPARγC161T (rs3856806), but the association was not significant. Our data provide evidence that East Asians with the variant type of CYP2E1 may have high susceptibility to development of CRC risk.
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