Financiado en parte por PepsiCo, Danone, Novo Nordisk Fonden, European Hydration Institute
Effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial
Carroll HA, Templeman I, Chen YC, Edinburgh RM, Burch EK, Jewitt JT, Povey G, Robinson TD, Dooley WL, Jones R, Tsintzas K, Gallo W, Melander O, Thompson D, James LJ, Johnson L, Betts JA
Journal of applied physiology (Bethesda, Md. : 1985) · 16 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- PepsiCo
- Empresa
- Danone
- Empresa
- Novo Nordisk Fonden
- Gobierno
- Economic and Social Research Council
- Empresa
- European Hydration Institute
- Gobierno
- Economic and Social Research Council (ESRC)
- Subvenciones
- Economic and Social Research Council (ES/J50015X/1); Economic and Social Research Council (1499599); Novo Nordisk Fonden (NNF14OC0009819)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2018-11-29 · J Appl Physiol (1985) · vol. 126 · número 2 · págs. 422–430
- Editorial
- American Physiological Society
- Citado
- 24 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Thermoregulation and physiological responses · Diet and metabolism studies · Muscle metabolism and nutrition
- Palabras clave
- Internal medicine, Medicine, Crossover study, Endocrinology, Glycemic, Insulin, Anabolism, Placebo
- MeSH
- muscle, skeletal, humans, dehydration, insulin, blood glucose, rehydration solutions, tomography, x-ray computed, glucose tolerance test, fluid therapy, pilot projects, cross-over studies, body composition, energy metabolism, time factors, adult, female, male, young adult, healthy volunteers, biomarkers, organism hydration status
17 autores
- Harriet A. Carroll🇬🇧 · autor de correspondenciaUniversity of Bath
- Iain Templeman🇬🇧University of Bath
- Yung‐Chih Chen🇬🇧University of Bath
- Robert M. Edinburgh🇬🇧University of Bath
- Elaine K. Burch🇬🇧University of Bath
- Jake T. Jewitt🇬🇧University of Bath
- Georgie Povey🇬🇧University of Bath
- Timothy D. Robinson🇬🇧University of Bath
- William L. Dooley🇬🇧University of Bath
- Robert Jones🇬🇧University of Nottingham
- Kostas Tsintzas🇬🇧University of Nottingham
- Widet Gallo🇸🇪Lund University
- Olle Melander🇸🇪Lund University
- Dylan Thompson🇬🇧University of Bath
- Lewis John James🇬🇧Loughborough University
- Laura Johnson🇬🇧University of Bristol
- James A. Betts🇬🇧University of Bath
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to investigate the acute effect of hydration status on glycemic regulation in healthy adults and explore underlying mechanisms. In this randomized crossover trial, 16 healthy adults (8 men, 8 women) underwent an oral glucose tolerance test (OGTT) when hypohydrated and rehydrated after 4 days of pretrial standardization. One day before OGTT, participants were dehydrated for 1 h in a heat tent with subsequent fluid restriction (HYPO) or replacement (RE). The following day, an OGTT was performed with metabolic rate measurements and pre- and post-OGTT muscle biopsies. Peripheral quantitative computer tomography thigh scans were taken before and after intervention to infer changes in cell volume. HYPO (but not RE) induced 1.9% (SD 1.2) body mass loss, 2.9% (SD 2.7) cell volume reduction, and increased urinary hydration markers, serum osmolality, and plasma copeptin concentration (all P ≤ 0.007). Fasted serum glucose [HYPO 5.10 mmol/l (SD 0.42), RE 5.02 mmol/l (SD 0.40); P = 0.327] and insulin [HYPO 27.1 pmol/l (SD 9.7), RE 27.6 pmol/l (SD 9.2); P = 0.809] concentrations were similar between HYPO and RE. Hydration status did not alter the serum glucose ( P = 0.627) or insulin ( P = 0.200) responses during the OGTT. Muscle water content was lower before OGTT after HYPO compared with RE [761 g/kg wet wt (SD 13) vs. 772 g/kg wet wt (SD 18) RE] but similar after OGTT [HYPO 779 g/kg wet wt (SD 15) vs. RE 780 g/kg wet wt (SD 20); time P = 0.011; trial × time P = 0.055]. Resting energy expenditure was similar between hydration states (stable between -1.21 and 5.94 kJ·kg-1·day-1; trial P = 0.904). Overall, despite acute mild hypohydration increasing plasma copeptin concentrations and decreasing fasted cell volume and muscle water, we found no effect on glycemic regulation. NEW & NOTEWORTHY We demonstrated for the first time that an acute bout of hypohydration does not impact blood sugar control in healthy adults. Physiological responses to mild hypohydration (<2% body mass loss) caused an elevation in copeptin concentrations similar to that seen in those with diabetes as well as reducing cell volume by ~3%; both of these changes had been hypothesized to cause a higher blood sugar response.
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