Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women
Caldwell JT, Sutterfield SL, Post HK, Craig JC, Baumfalk DR, Copp SW, Ade CJ
Medicine and science in sports and exercise · 11 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-12-07 · Med Sci Sports Exerc · vol. 51 · número 5 · págs. 1014–1021
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 25 citas · más que el 81% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- Medicine, Blood pressure, Forearm, Placebo, Brachial artery, Heart rate, Cardiology, Internal medicine, Blood flow, Diastole, Sphygmomanometer, Dietary Nitrate, Hemodynamics, Anesthesia, Surgery, Nitrate, Chemistry, Pathology, Nitrite
- MeSH
- forearm, brachial artery, humans, beta vulgaris, hypertension, nitrates, nitrites, hand strength, exercise, cross-over studies, double-blind method, postmenopause, blood pressure, exercise tolerance, dietary supplements, middle aged, female, hemodynamics, fruit and vegetable juices
7 autores
- Jacob T. Caldwell🇺🇸Kansas State University
- Shelbi L. Sutterfield🇺🇸Kansas State University
- Hunter K. Post🇺🇸Kansas State University
- Jesse C. Craig🇺🇸Kansas State University
- Dryden Ray Baumfalk🇺🇸Kansas State University
- Steven W. Copp🇺🇸Kansas State University
- Carl J. Ade🇺🇸Kansas State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
the aim of the current investigation was to examine if dietary nitrate supplementation would improve vascular control in hypertensive postmenopausal women (PMW). We tested the hypotheses that acute dietary nitrate supplementation would 1) significantly decrease arterial blood pressure (BP) at rest and during exercise, 2) increase limb blood flow during steady-state (SS) exercise, and 3) improve functional sympatholysis during SS exercise.
Methods
Ten hypertensive PMW underwent a randomized, double-blind, placebo-controlled trial with a nitrate-rich (NR) or nitrate-poor (NP) supplement. Beat-by-beat BP and heart rate were recorded throughout the trial on the nonexercising limb. Forearm blood flow was measured via ultrasonography on the brachial artery of the exercising limb. All patients performed a resting cold pressor test (CPT) (2 min) and then 7 min of submaximal handgrip exercise with a CPT applied during minutes 5-7.
Results
SS systolic (NR, 170 ± 7; NP, 171 ± 37 mm Hg), diastolic (NR, 89 ± 2; NP, 92 ± 2 mm Hg), and mean arterial (NR, 121 ± 4; NP, 123 ± 2 mm Hg) pressures were not different between NP and NR treatment conditions (P > 0.05). During SS exercise, forearm blood flow (NR, 189 ± 8; NP, 218 ± 8 mL·min; P = 0.03) in the NR treatment was significantly lower compared with NP. When the CPT was applied during minutes 6-7 of exercise, forearm vascular conductance was reduced by 15% in the NR condition, but only 7% in the NR condition.
Conclusions
In summary, an acute NR supplement improved functional sympatholysis by ~50% versus an NP placebo condition. Improvements in functional sympatholysis may have important implications regarding exercise tolerance in hypertensive PMW.
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