Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
Wang Z, Bergeron N, Levison BS, Li XS, Chiu S, Jia X, Koeth RA, Li L, Wu Y, Tang WHW, Krauss RM, Hazen SL
European heart journal · 389 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Dietary Supplements
- Organización sin fines de lucro
- Fondation Leducq
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of California, San Francisco
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Universidad u hospital
- Clinical and Translational Science Unit
- Gobierno
- NHLBI NIH HHS
- Organización sin fines de lucro
- Leducq Foundation
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL126827); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK106000); Office of Dietary Supplements (R01 HL103866); Office of Dietary Supplements (HL126827); National Heart, Lung, and Blood Institute (R01HL130819); National Heart, Lung, and Blood Institute (R01HL103866); Office of Dietary Supplements (DK106000); Office of Dietary Supplements (HL103866); National Heart, Lung, and Blood Institute (R01 HL106003); National Institutes of Health (R01HL130819); National Institutes of Health (R01 DK106000); National Institutes of Health (RO1 HL106003); National Institutes of Health (HL103866); National Institutes of Health (R01HL126827)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2018-11-19 · Eur Heart J · vol. 40 · número 7 · págs. 583–594
- Editorial
- Oxford University Press
- Citado
- 500 citas · más que el 100% de estudios similares · 24.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Metabolism and Genetic Disorders · Gut microbiota and health · Folate and B Vitamins Research
- Palabras clave
- Medicine, White meat, Trimethylamine N-oxide, Red meat, Excretion, Food science, Cooked meat, Trimethylamine, Internal medicine, Biochemistry, Pathology
- MeSH
- animals, poultry, humans, methylamines, dietary proteins, diet, cross-over studies, feeding behavior, reference values, adult, aged, middle aged, female, male, young adult, renal elimination, red meat
12 autores
- Zeneng Wang🇺🇸Cleveland Clinic Lerner College of Medicine
- Nathalie Bergeron🇺🇸Touro University California
- Bruce S. Levison🇺🇸Cleveland Clinic Lerner College of Medicine
- Xinmin S. Li🇺🇸Cleveland Clinic Lerner College of Medicine
- Sally Chiu
- Xun Jia🇺🇸Cleveland Clinic Lerner College of Medicine
- Robert Koeth🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Lin Li🇺🇸Cleveland Clinic Lerner College of Medicine
- Yuping Wu🇺🇸Cleveland State University
- W.H. Wilson Tang🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Ronald M. Krauss
- Stanley L. Hazen🇺🇸 · autor de correspondenciaCleveland Clinic; Cleveland Clinic Lerner College of Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
Carnitine and choline are major nutrient precursors for gut microbiota-dependent generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed randomized-controlled dietary intervention studies to explore the impact of chronic dietary patterns on TMAO levels, metabolism and renal excretion.
Methods and results
Volunteers (N = 113) were enrolled in a randomized 2-arm (high- or low-saturated fat) crossover design study. Within each arm, three 4-week isocaloric diets (with washout period between each) were evaluated (all meals prepared in metabolic kitchen with 25% calories from protein) to examine the effects of red meat, white meat, or non-meat protein on TMAO metabolism. Trimethylamine N-oxide and other trimethylamine (TMA) related metabolites were quantified at the end of each diet period. A random subset (N = 13) of subjects also participated in heavy isotope tracer studies. Chronic red meat, but not white meat or non-meat ingestion, increased plasma and urine TMAO (each >two-fold; P < 0.0001). Red meat ingestion also significantly reduced fractional renal excretion of TMAO (P < 0.05), but conversely, increased fractional renal excretion of carnitine, and two alternative gut microbiota-generated metabolites of carnitine, γ-butyrobetaine, and crotonobetaine (P < 0.05). Oral isotope challenge revealed red meat or white meat (vs. non-meat) increased TMA and TMAO production from carnitine (P < 0.05 each) but not choline. Dietary-saturated fat failed to impact TMAO or its metabolites.
Conclusion
Chronic dietary red meat increases systemic TMAO levels through: (i) enhanced dietary precursors; (ii) increased microbial TMA/TMAO production from carnitine, but not choline; and (iii) reduced renal TMAO excretion. Discontinuation of dietary red meat reduces plasma TMAO within 4 weeks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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