Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial
Dai Q, Zhu X, Manson JE, Song Y, Li X, Franke AA, Costello RB, Rosanoff A, Nian H, Fan L, Murff H, Ness RM, Seidner DL, Yu C, Shrubsole MJ
The American journal of clinical nutrition · 148 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Universidad u hospital
- Vanderbilt University
- Universidad u hospital
- Vanderbilt Institute for Clinical and Translational Research
- Universidad u hospital
- Georgia Clinical and Translational Science Alliance
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCI NIH HHS
- Universidad u hospital
- Survey and Biospecimen Shared Resource
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- Department of Health and Human Services
- Universidad u hospital
- Vanderbilt
- Gobierno
- NCRR NIH HHS
- Universidad u hospital
- Ingram Cancer Center Endowment
- Subvenciones
- Georgia Clinical and Translational Science Alliance (UL1 RR024975); National Cancer Institute (P30 CA 68485); Georgia Clinical and Translational Science Alliance (RR024975); Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445); Vanderbilt Institute for Clinical and Translational Research (RR024975); Georgia Clinical and Translational Science Alliance (UL1TR000445); National Cancer Institute (R01 CA202936); National Cancer Institute (R03 CA189455); Vanderbilt University (UL1 RR024975); National Center for Research Resources (RR024975); Vanderbilt University (UL1‐TR000445); National Cancer Institute (P30 CA 068485); Vanderbilt Institute for Clinical and Translational Research (UL1 RR024975); National Cancer Institute (R01CA149633); National Institutes of Health (UL1TR000445); National Institutes of Health (UL1-RR024975); National Institutes of Health (P30CA68485)); National Institutes of Health (RR024975); National Institutes of Health (R01 CA202936); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK058404); National Cancer Institute (P30CA071789); National Center for Research Resources (UL1-RR024975)
Según 17 financiadores declarados.
Publicación
- Publicado
- 2018-10-04 · Am J Clin Nutr · vol. 108 · número 6 · págs. 1249–1258
- Editorial
- Elsevier BV
- Citado
- 198 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Vitamin D Research Studies · Nutritional Studies and Diet
- Palabras clave
- magnesium supplementation, vitamin D status, vitamin D metabolism, 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D, vitamin D2, vitamin D3, magnesium-dependent enzyme, dietary magnesium, colorectal cancer prevention
- MeSH
- kidney, humans, vitamin d deficiency, magnesium deficiency, magnesium, calcifediol, calcitriol, 24,25-dihydroxyvitamin d 3, ergocalciferols, 25-hydroxyvitamin d 2, vitamin d, placebos, nutritional status, dietary supplements, aged, middle aged, female, male
15 autores
- Qi Dai🇺🇸 · autor de correspondenciaVanderbilt University; Vanderbilt-Ingram Cancer Center; Vanderbilt University Medical Center
- Xiangzhu Zhu🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center; Vanderbilt University Medical Center
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Yiqing Song🇺🇸Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Xingnan Li🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii Cancer Center
- Adrian A. Franke🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii Cancer Center
- Rebecca B. Costello
- Andrea Rosanoff
- Hui Nian
- Lei Fan
- Harvey J. Murff🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center; Vanderbilt University Medical Center
- Reid M. Ness🇺🇸Vanderbilt University
- Douglas L. Seidner🇺🇸Vanderbilt University
- Chang Yu
- Martha J. Shrubsole🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center; Vanderbilt University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium.
Objectives
The aim of this study was to test the hypothesis that magnesium supplementation differentially affects vitamin D metabolism dependent on baseline 25-hydroxyvitamin D [25(OH)D] concentration.
Methods
The study included 180 participants aged 40-85 y and is a National Cancer Institute independently funded ancillary study, nested within the Personalized Prevention of Colorectal Cancer Trial (PPCCT), which enrolled 250 participants. The PPCCT is a double-blind 2 × 2 factorial randomized controlled trial conducted in the Vanderbilt University Medical Center. Doses for both magnesium and placebo were customized based on baseline dietary intakes. Subjects were randomly assigned to treatments using a permuted-block randomization algorithm. Changes in plasma 25-hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2 [25(OH)D2], 1,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D2, and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] were measured by liquid chromatography-mass spectrometry.
Results
The relations between magnesium treatment and plasma concentrations of 25(OH)D3, 25(OH)D2, and 24,25(OH)2D3 were significantly different dependent on the baseline concentrations of 25(OH)D, and significant interactions persisted after Bonferroni corrections. Magnesium supplementation increased the 25(OH)D3 concentration when baseline 25(OH)D concentrations were close to 30 ng/mL, but decreased it when baseline 25(OH)D was higher (from ∼30 to 50 ng/mL). Magnesium treatment significantly affected 24,25(OH)2D3 concentration when baseline 25(OH)D concentration was 50 ng/mL but not 30 ng/mL. On the other hand, magnesium treatment increased 25(OH)D2 as baseline 25(OH)D increased.
Conclusion
Our findings suggest that optimal magnesium status may be important for optimizing 25(OH)D status. This trial was registered at clinicaltrials.gov as NCT03265483.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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