Financiado en parte por Cereal Partners Worldwide
A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
Schutte S, Esser D, Hoevenaars FPM, Hooiveld GJEJ, Priebe MG, Vonk RJ, Wopereis S, Afman LA
The American journal of clinical nutrition · 62 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- European Commission
- Gobierno
- Seventh Framework Programme
- Empresa
- Cereal Partners Worldwide
- Gobierno
- European Commission in the 7th Framework Programme
- Subvenciones
- Seventh Framework Programme (613979); European Commission (613979)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2018-08-17 · Am J Clin Nutr · vol. 108 · número 6 · págs. 1264–1274
- Editorial
- Elsevier BV
- Citado
- 73 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- whole wheat, liver fat, non-alcoholic fatty liver disease, intrahepatic triglyceride, gut microbiota, postprandial triglycerides, serum amyloid A, C-reactive protein, adipose tissue gene expression, overweight adults, postmenopausal women, dietary intervention
- MeSH
- liver, adipose tissue, feces, humans, triticum, fatty liver, triglycerides, diet, double-blind method, body composition, postmenopause, food handling, dietary fiber, aged, middle aged, netherlands, female, male, adiposity, overweight, lipid metabolism, gastrointestinal microbiome, whole grains
8 autores
- Sophie Schutte🇳🇱Wageningen University & Research
- Diederik Esser🇳🇱Wageningen University & Research
- Femke P. M. Hoevenaars🇳🇱Netherlands Organisation for Applied Scientific Research
- Guido J. E. J. Hooiveld🇳🇱Wageningen University & Research
- Marion G. Priebe🇳🇱University Medical Center Groningen; University of Groningen
- Roel J. Vonk🇳🇱University Medical Center Groningen; University of Groningen
- Suzan Wopereis🇳🇱Netherlands Organisation for Applied Scientific Research
- Lydia A. Afman🇳🇱 · autor de correspondenciaWageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.
Objective
The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters.
Design
We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.
Results
Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention.
Conclusions
A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149.
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