Toxic doses of caffeine are needed to increase skeletal muscle contractility
Neyroud D, Cheng AJ, Donnelly C, Bourdillon N, Gassner AL, Geiser L, Rudaz S, Kayser B, Westerblad H, Place N
American journal of physiology. Cell physiology · 27 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Centrum för idrottsforskning
- Universidad u hospital
- Université de Lausanne
- Gobierno
- Swedish Research Council for Sport Science
- Gobierno
- Swedish Research Council
- Universidad u hospital
- University of Lausanne
- Subvenciones
- Vetenskapsrådet (K2014‐52X‐10842‐21‐5); Centrum för idrottsforskning (FO2018-0019); Centrum för idrottsforskning (FO2016-033)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2018-12-19 · Am J Physiol Cell Physiol · vol. 316 · número 2 · págs. C246–C251
- Editorial
- American Physical Society
- Citado
- 41 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Exercise and Physiological Responses · Cardiovascular and exercise physiology
- Palabras clave
- Caffeine, Contractility, Chemistry, Endocrinology, Internal medicine, Skeletal muscle, Muscle contraction, Medicine
- MeSH
- muscle, skeletal, animals, mice, inbred c57bl, humans, mice, caffeine, electromyography, organ culture techniques, muscle contraction, dose-response relationship, drug, adult, female, male, young adult
10 autores
- Daria Neyroud🇨🇭 · autor de correspondenciaUniversity of Lausanne
- Arthur J. Cheng🇸🇪Karolinska Institutet
- Chris Donnelly🇨🇭University of Lausanne
- Nicolas Bourdillon🇨🇭University of Lausanne
- Anne‐Laure Gassner🇨🇭University of Geneva; University of Lausanne
- Laurent Geiser🇨🇭University of Geneva; University of Lausanne
- Serge L. Rudaz🇨🇭University of Geneva; University of Lausanne
- Bengt Kayser🇨🇭University of Lausanne
- Håkan Westerblad🇸🇪Karolinska Institutet
- Nicolas Place🇨🇭University of Lausanne
Resumen
El texto original del estudio, en el idioma en que se publicó.
Discrepant results have been reported regarding an intramuscular mechanism underlying the ergogenic effect of caffeine on neuromuscular function in humans. Here, we reevaluated the effect of caffeine on muscular force production in humans and combined this with measurements of the caffeine dose-response relationship on force and cytosolic free [Ca2+] ([Ca2+]i) in isolated mouse muscle fibers. Twenty-one healthy and physically active men (29 ± 9 yr, 178 ± 6 cm, 73 ± 10 kg, mean ± SD) took part in the present study. Nine participants were involved in two experimental sessions during which supramaximal single and paired electrical stimulations (at 10 and 100 Hz) were applied to the femoral nerve to record evoked forces. Evoked forces were recorded before and 1 h after ingestion of 1) 6 mg caffeine/kg body mass or 2) placebo. Caffeine plasma concentration was measured in 12 participants. In addition, submaximal tetanic force and [Ca2+]i were measured in single mouse flexor digitorum brevis (FDB) muscle fibers exposed to 100 nM up to 5 mM caffeine. Six milligrams of caffeine per kilogram body mass (plasma concentration ~40 µM) did not increase electrically evoked forces in humans. In superfused FDB single fibers, millimolar caffeine concentrations (i.e., 15- to 35-fold above usual concentrations observed in humans) were required to increase tetanic force and [Ca2+]i. Our results suggest that toxic doses of caffeine are required to increase muscle contractility, questioning the purported intramuscular ergogenic effect of caffeine in humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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