Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients Are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults
Ter Borg S, Luiking YC, van Helvoort A, Boirie Y, Schols JMGA, de Groot CPGM
The journal of nutrition, health & aging · 64 citas
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Alexander von Humboldt-Stiftung
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-10-13 · J Nutr Health Aging · vol. 23 · número 1 · págs. 27–34
- Editorial
- Springer Science+Business Media
- Citado
- 70 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Frailty in Older Adults
- Palabras clave
- Sarcopenia, Eicosapentaenoic acid, Internal medicine, Medicine, Homocysteine, Endocrinology, Docosahexaenoic acid, Skeletal muscle, Micronutrient, Amino acid, Polyunsaturated fatty acid, Chemistry, Fatty acid, Biochemistry
- MeSH
- muscle, skeletal, humans, eicosapentaenoic acid, micronutrients, amino acids, branched-chain, cross-sectional studies, aged, aged, 80 and over, female, male, sarcopenia, independent living
6 autores
- Sovianne ter Borg🇫🇷🇳🇱Danone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands)
- Yvette C. Luiking🇺🇸🇫🇷🇳🇱 · autor de correspondenciaTexas A&M University System; Danone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands); Texas A&M University
- Ardy van Helvoort🇳🇱🇫🇷Maastricht University; Danone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands)
- Yves Boirie🇫🇷Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; University of Clermont Auvergne; Centre de Recherche en Nutrition Humaine Rhône-Alpes; Centre Hospitalier Universitaire de Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
- Jos M. G. A. Schols🇳🇱🇳🇵Maastricht University; Department of Health Services
- C.P.G.M. de Groot🇳🇱Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sarcopenia, the age-related decrease in muscle mass and function can result in adverse health outcomes and subsequent loss of independence. Inadequate nutrition is an important contributor to the aetiology of sarcopenia, and dietary strategies are studied to prevent or delay this geriatric syndrome.
Objective
The present study investigated whether there is an association between biochemical nutrient status markers, muscle parameters and sarcopenia in community-dwelling older adults.
Design
Data from the cross-sectional Maastricht Sarcopenia study (MaSS) were used, in which skeletal muscle index (SMI), 4 meter gait speed, 5 times chair stand and handgrip strength were assessed among older adults (n=227). Sarcopenia was defined following the algorithm of the European Working Group on Sarcopenia in Older People. Fasted blood samples were analyses on amino acids levels, RBC phospholipid profile, 25-hydroxyvitamin D (25(OH)D), α-tocopherol, magnesium and homocysteine were determined in fasted blood levels. Generalized linear modelling and logistic regression were used for data analysis.
Results
Lower blood levels of essential amino acids (EAA), total branched-chain amino acids (BCAA) and leucine were associated with lower SMI (P<0.001), strength (P<0.001) and longer time to complete the chair stand (P<0.05), whereas no association was found for total amino acids (TAA). Lower levels of eicosapentaenoic acid (EPA), 25(OH)D and homocysteine were associated with lower muscle parameter values (P<0.05). No significant associations were found for SFA, MUFA, PUFA, n-3 and n-6 fatty acids, docosahexaenoic acid (DHA), α-tocopherol-cholesterol ratio and magnesium. Sarcopenia was more frequent among those with lower levels of leucine, BCAA, EAA, EPA, 25(OH)D and higher levels of homocysteine (P<0.05). Age and BMI were identified as relevant covariates. A robust association was only found for lower gait speed and lower 25(OH)D levels.
Conclusion
Compromised muscle parameters are associated with low blood values of specific amino acids, fatty acids, vitamin D and high homocysteine.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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