Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise in untreated hypertensives
Zafeiridis A, Triantafyllou A, Papadopoulos S, Koletsos N, Touplikioti P, Zafeiridis AS, Gkaliagkousi E, Dipla K, Douma S
Microcirculation (New York, N.Y. : 1994) · 20 citas
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2018-12-26 · Microcirculation · vol. 26 · número 3 · pág. e12525
- Editorial
- Wiley
- Citado
- 22 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Palabras clave
- Medicine, Isometric exercise, Cardiology, Arterial stiffness, Pulse wave velocity, Internal medicine, Hemoglobin, Blood pressure, Anesthesia
- MeSH
- humans, hypertension, nitrates, hand strength, exercise, double-blind method, blood pressure, vascular resistance, dietary supplements, adult, middle aged, female, male, hemodynamics, vascular stiffness, pulse wave analysis
11 autores
- Andreas Zafeiridis🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Andreas Zafeiridis🇬🇷 · autor de correspondenciaAristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Areti Triantafyllou🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital
- Stavros Papadopoulos🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Nikolaos Koletsos🇬🇷Theageneio General Hospital; Papageorgiou General Hospital
- Panagiota Touplikioti🇬🇷Aristotle University of Thessaloniki; Theageneio General Hospital; Papageorgiou General Hospital
- Alexandros S. Zafeiridis🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Alexandros S. Zafeiridis🇬🇷 · autor de correspondenciaAristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Eugenia Gkaliagkousi🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital
- Konstantina Dipla🇬🇷Aristotle University of Thessaloniki; General Hospital of Serres
- Στέλλα Δούμα🇬🇷Papageorgiou General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This double-blind, cross-over study examined in drug-naïve hypertensives the effects of a single dose of dietary nitrate (beetroot juice, BRJ) on (a) office/ambulatory BP and arterial stiffness, (b) muscle microvascular function, and (c) hemodynamic responses and cardiovagal baroreceptor sensitivity (cBRS) at rest and during isometric exercise.
Methods
Eighteen untreated hypertensives (44.0 ± 2.6 years) consumed randomly, a nitrate-rich (8.1 mmol-BRJnitrate ) and a nitrate-depleted (BRJplacebo ) BRJ. Office BP and pulse wave velocity were assessed before/after BRJ. An occlusion-reperfusion maneuver with continuous monitoring of muscle oxygenated hemoglobin (O2 Hb) and total hemoglobin (tHb), via NIRS, followed. Participants performed submaximal isometric handgrip with beat-by-beat monitoring of hemodynamics and cBRS. Ambulatory BP assessment followed.
Results
During reperfusion, following arterial occlusion, the magnitude and rate of muscle microvascular reoxygenation (O2 Hb) and red blood cell content (tHb) were higher in BRJnitrate vs BRJplacebo (P nitrate vs BRJplacebo (P nitrate vs BRJplacebo (P < 0.01-0.05), with no differences in cBRS.
Conclusions
In drug-naïve hypertensives, a single dose of BRJ induces (a) short-term reductions in resting/ambulatory BP, (b) acute improvements in muscle microvascular function, and (c) attenuation in BP and peripheral resistance responses during isometric exercise.
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