Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh
Bozack AK, Hall MN, Liu X, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV
The American journal of clinical nutrition · 48 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA133595); National Institute of Environmental Health Sciences (R01 ES017875); National Center for Advancing Translational Sciences (TL1‐TR001875); National Institute of Environmental Health Sciences (P42ES010349); National Institute of Environmental Health Sciences (F31ES029019); National Institute of Environmental Health Sciences (#T32ES007322); National Institute of Environmental Health Sciences (F31 ES029019:AKB); National Cancer Institute (R01 CA133595:MVG); National Institute of Environmental Health Sciences (R01 ES017875:MVG); National Institute of Environmental Health Sciences (P30ES009089)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2018-06-19 · Am J Clin Nutr · vol. 109 · número 2 · págs. 380–391
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 87% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Arsenic contamination and mitigation · Heavy Metal Exposure and Toxicity · Folate and B Vitamins Research
- Palabras clave
- folic acid supplementation, creatine supplementation, arsenic methylation, inorganic arsenic, dimethylarsinic acid, urinary arsenic metabolites, one-carbon metabolism, folic acid, drinking water arsenic exposure
- MeSH
- humans, folic acid deficiency, mercury poisoning, arsenicals, arsenic, creatine, folic acid, vitamin b complex, water pollutants, chemical, nutrition therapy, cross-sectional studies, environmental exposure, methylation, dietary supplements, adult, middle aged, bangladesh, female, male, young adult, inactivation, metabolic
12 autores
- Anne K. Bozack
- Megan N. Hall
- Xinhua Liu🇺🇸Columbia University
- Vesna Ilievski
- Angela M. Lomax-Luu
- Faruque Parvez
- Abu B Siddique🇺🇸Columbia University
- Hasan Shahriar🇺🇸Columbia University
- Mohammad Nasir Uddin🇺🇸Columbia University
- Tariqul Islam🇺🇸Columbia University
- Joseph H. Graziano
- Mary V. Gamble · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced by nutritional factors such as folate and creatine.
Objective
This study investigated the effects of folic acid (FA) and/or creatine supplementation on the proportion of As metabolites in urine.
Design
In a 24-wk randomized, double-blinded, placebo-controlled trial, 622 participants were assigned to receive FA (400 or 800 μg per day), 3 g creatine per day, 400 μg FA + 3 g creatine per day, or placebo. The majority of participants were folate sufficient; all received As-removal water filters. From wk 12-24, half of the participants receiving FA received placebo.
Results
Among groups receiving FA, the mean decrease in ln(%InAs) and %MMAs and increase in %DMAs exceeded those of the placebo group at wk 6 and 12 (P < 0.05). In the creatine group, the mean decrease in %MMAs exceeded that of the placebo group at wk 6 and 12 (P < 0.05); creatine supplementation did not affect change in %InAs or %DMAs. The decrease in %MMAs at wk 6 and 12 was larger in the 800 µg FA than in the 400 µg FA group (P = 0.034). There were no differences in treatment effects between the 400 µg FA and creatine + FA groups. Data suggest a rebound in As metabolite proportions after FA cessation; at wk 24, log(%InAs) and %DMAs were not significantly different than baseline levels among participants who discontinued FA supplementation.
Conclusions
The results of this study confirm that FA supplementation rapidly and significantly increases methylation of InAs to DMAs. Further research is needed to understand the strong cross-sectional associations between urinary creatinine and As methylation in previous studies. This trial was registered at https://clinicaltrials.gov as NCT01050556.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.