Financiado en parte por Egg Nutrition Center, American Egg Board/Egg Nutrition Center
Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol
Vincent MJ, Allen B, Palacios OM, Haber LT, Maki KC
The American journal of clinical nutrition · 73 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Egg Nutrition Center
- Grupo de la industria
- American Egg Board/Egg Nutrition Center
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-10-09 · Am J Clin Nutr · vol. 109 · número 1 · págs. 7–16
- Editorial
- Elsevier BV
- Citado
- 106 citas · más que el 99% de estudios similares · 8.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Nutritional Studies and Diet
- Palabras clave
- dietary cholesterol, LDL cholesterol, HDL cholesterol, dose-response relationship, saturated fatty acids, trans fatty acids, cardiovascular risk, Michaelis-Menten model, Hill model, sex differences, lipoprotein cholesterol
- MeSH
- humans, cardiovascular diseases, cholesterol, dietary fats, cholesterol, dietary, fatty acids, monte carlo method, bayes theorem, risk factors, regression analysis, sex factors, dose-response relationship, drug, female, male, cholesterol, ldl, cholesterol, hdl, cholesterol, vldl
5 autores
- Melissa Vincent🇺🇸 · autor de correspondenciaUniversity of Cincinnati
- Bruce C. Allen
- Orsolya M Palacios🇺🇸MB Clinical Research and Consulting (United States)
- Lynne T. Haber🇺🇸University of Cincinnati
- Kevin Carl Maki🇺🇸MB Clinical Research and Consulting (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guidance recommends reducing saturated fatty acid, trans fatty acid, and cholesterol intakes to reduce circulating LDL cholesterol. Cholesterol intake may also affect high-density lipoprotein (HDL)-cholesterol concentrations, but its impact has not been fully quantified.
Objectives
The aims of this study were to investigate the dose-response relation between changes in dietary cholesterol intake and changes in lipoprotein-cholesterol markers for cardiovascular disease risk and to provide a reference for clinicians on how changes in dietary cholesterol intake affect circulating cholesterol concentrations, after accounting for intakes of fatty acids.
Methods
We used a Bayesian approach to meta-regression analysis, which uses Markov chain Monte Carlo techniques, to assess the relation between the change in dietary cholesterol (adjusted for dietary fatty acids) and changes in LDL and HDL cholesterol based on the use of data from randomized dietary intervention trials.
Results
Fifty-five studies (2652 subjects) were included in the analysis. The nonlinear Michaelis-Menten (MM) and Hill models best described the data across the full spectrum of dietary cholesterol changes studied (0-1500 mg/d). Mean predicted changes in LDL cholesterol for an increase of 100 mg dietary cholesterol/d were 1.90, 4.46, and 4.58 mg/dL for the linear, nonlinear MM, and Hill models, respectively.
Conclusions
The change in dietary cholesterol was positively associated with the change in LDL-cholesterol concentration. The linear and MM models indicate that the change in dietary cholesterol is modestly inversely related to the change in circulating HDL-cholesterol concentrations in men but is positively related in women. The clinical implications of HDL-cholesterol changes associated with dietary cholesterol remain uncertain.
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