Increased water intake reduces long-term renal and cardiovascular disease progression in experimental polycystic kidney disease
Sagar PS, Zhang J, Luciuk M, Mannix C, Wong ATY, Rangan GK
PloS one · 19 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (1138533, 632674); National Health and Medical Research Council (1138533); National Health and Medical Research Council (632674)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-02 · PLoS One · vol. 14 · número 1 · pág. e0209186
- Editorial
- Public Library of Science
- Citado
- 25 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genetic and Kidney Cyst Diseases · Renal and related cancers · Genetic Syndromes and Imprinting
- Palabras clave
- Polycystic kidney disease, Internal medicine, Endocrinology, Kidney, Autosomal dominant polycystic kidney disease, Kidney disease, Medicine, Cyst, Renal function, Blood pressure, Biology, Pathology
- MeSH
- kidney, animals, rats, inbred lew, humans, rats, polycystic kidney diseases, cardiovascular diseases, disease models, animal, disease progression, fibrosis, creatinine, organ size, drinking, osmolar concentration, female, male
6 autores
- Priyanka S. Sagar🇦🇺 · autor de correspondenciaThe University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
- Jennifer Q. J. Zhang🇦🇺The University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
- Magdalena Luciuk🇦🇺The University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
- Carly Mannix🇦🇺The University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
- Annette T. Y. Wong🇦🇺The University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
- Gopala K. Rangan🇦🇺The University of Sydney; Westmead Hospital; Sydney Local Health District; Westmead Institute for Medical Research; Western Sydney Local Health District
Resumen
El texto original del estudio, en el idioma en que se publicó.
Polycystic kidney disease (PKD) is the most common inherited cause of kidney failure and currently has limited treatment options. Increasing water intake reduces renal cyst growth in the pck rat (a genetic ortholog of autosomal recessive PKD) but it is not clear if this beneficial effect is present in other models of PKD. In this study, we tested the hypothesis that high water intake (HWI) reduces the progression of cystic renal disease in Lewis polycystic kidney (LPK) rats (a genetic ortholog of human nephronophthisis-9). Groups of female and male LPK (n = 8-10 per group) and Lewis (n = 4 per group) rats received water ad libitum supplemented with or without 5% glucose [to simulate HWI or normal water intake (NWI) respectively] from postnatal weeks 3 to 16. Water intake increased ~1.3-fold in the LPK+HWI group compared to LPK+NWI rats between weeks 3 to 10 but the differences were not significant at later timepoints. In LPK rats, HWI reduced the increases in the kidney to body weight ratio by 54% at week 10 and by 42% at week 16 compared to NWI (both p<0.01). The reduction in kidney enlargement was accompanied by decreases in the percentage renal cyst area, percentage renal interstitial collagen and proteinuria (all p<0.05). At week 16, HWI reduced systolic blood pressure and the heart to body to weight ratio by 16% and 21% respectively in males LPK rats (both p<0.01). In conclusion, a modest increase in water intake during the early phase of disease was sufficient to attenuate renal cystic disease in LPK rats, with secondary benefits on hypertension and cardiovascular disease. These data provide further preclinical evidence that increased water intake is a potential intervention in cystic renal diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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