Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial
Cho AR, Moon JY, Kim S, An KY, Oh M, Jeon JY, Jung DH, Choi MH, Lee JW
Metabolism: clinical and experimental · 78 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation of Korea
- Universidad u hospital
- Yonsei University College of Medicine
- Subvenciones
- National Research Foundation of Korea (NRF-2018R1D1A1B07049223); National Research Foundation of Korea (NRF-2013M3A9B6046413); Yonsei University College of Medicine (6-2013-0021)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-01-04 · Metabolism · vol. 93 · págs. 52–60
- Editorial
- Elsevier BV
- Citado
- 99 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Dietary Effects on Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- alternate-day fasting, physical activity, cholesterol metabolism, serum sterols, cholesterol biosynthesis, cholesterol absorption, phytosterols, desmosterol, 7-dehydrocholesterol, oxysterols, cholesterol esters, overweight, obesity, weight loss, caloric restriction
- MeSH
- humans, obesity, weight loss, cholesterol, sterols, exercise, caloric restriction, fasting, pilot projects, adult, female, male, overweight, gas chromatography-mass spectrometry
9 autores
- A‐Ra Cho🇰🇷Yonsei University; Gangnam Severance Hospital
- Ju‐Yeon Moon🇰🇷Korea Institute of Science and Technology
- Sue Kim🇰🇷Severance Hospital; Yonsei University Health System
- Ki‐Yong An🇨🇦University of Alberta
- Minsuk Oh🇺🇸University of Iowa
- Justin Y. Jeon🇰🇷Yonsei University
- Dong‐Hyuk Jung🇰🇷Yonsei University; Severance Hospital; Yongin Severance Hospital
- Man Ho Choi🇰🇷 · autor de correspondenciaKorea Institute of Science and Technology
- Ji‐Won Lee🇰🇷 · autor de correspondenciaYonsei University; Gangnam Severance Hospital; Yonsei University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and purpose
The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.
Methods
We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography-mass spectrometry.
Results
After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p < 0.05 by analysis of covariance [ANCOVA]). We found no differences in plant sterols, which are markers of cholesterol absorption. In the exercise group, desmosterol, cholesteryl esters, and oxysterols decreased significantly. Furthermore, only changes in physical activity levels negatively correlated with changes in the metabolic ratios of desmosterol and 7-dehydrocholesterol to cholesterol, which reflect cholesterol biosynthesis (r = -0.411; p = 0.030, and r = -0.540; p = 0.003, respectively).
Conclusion
These findings suggest that exercise with or without ADF improves cholesterol metabolism as measured by serum sterol signatures, and increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.