Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women
McGlory C, Gorissen SHM, Kamal M, Bahniwal R, Hector AJ, Baker SK, Chabowski A, Phillips SM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 131 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- CIHR
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-01-10 · FASEB J · vol. 33 · número 3 · págs. 4586–4597
- Editorial
- Wiley
- Citado
- 151 citas · más que el 96% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle Physiology and Disorders · Muscle metabolism and nutrition · Fatty Acid Research and Health
- Palabras clave
- omega-3 fatty acids, disuse atrophy, skeletal muscle, immobilization, myofibrillar protein synthesis, muscle mass, muscle volume, young women, dietary supplementation, muscle protein synthesis
- MeSH
- knee, myofibrils, body water, humans, muscular atrophy, dietary fats, fatty acids, omega-3, phospholipids, muscle proteins, biopsy, organ size, double-blind method, immobilization, gene expression regulation, body composition, reference values, dietary supplements, adult, female, quadriceps muscle, muscle strength, young adult, sunflower oil
8 autores
- Chris McGlory🇨🇦 · autor de correspondenciaMcMaster University
- Stefan H. M. Gorissen🇨🇦McMaster University
- Michael J. Kamal🇨🇦McMaster University
- Ravninder Bahniwal🇨🇦McMaster University
- Amy J. Hector🇨🇦McMaster University
- Steven K. Baker🇨🇦McMaster University
- Adrian Chabowski🇵🇱Medical University of Białystok
- Stuart M. Phillips🇨🇦McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Omega-3 (n-3) fatty acid supplementation enhances muscle protein synthesis and muscle size. Whether n-3 fatty acid supplementation attenuates human muscle disuse atrophy is unknown. We determined the influence of n-3 fatty acid supplementation on muscle size, mass, and integrated rates of myofibrillar protein synthesis (MyoPS) following 2 wk of muscle disuse and recovery in women. Twenty women (BMI = 23.0 ± 2.3 kg/m2, age = 22 ± 3 yr) underwent 2 wk of unilateral limb immobilization followed by 2 wk of return to normal activity. Starting 4 wk prior to immobilization, participants consumed either 5 g/d of n-3 fatty acid or an isoenergetic quantity of sunflower oil (control). Muscle size and mass were measured pre- and postimmobilization, and after recovery. Serial muscle biopsies were obtained to measure integrated (daily) MyoPS. Following immobilization, the decline in muscle volume was greater in the control group compared to the n-3 fatty acid group (14 vs. 8%, P < 0.05) and was not different from preimmobilization at recovery in the n-3 fatty acid group; however, it was still lower in the control group ( P < 0.05). Muscle mass was reduced in the control group only ( P < 0.05). MyoPS was higher in the n-3 group compared with the control group at all times ( P < 0.05). We conclude that n-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy in young women, which may be mediated by higher rates of MyoPS.-McGlory, C., Gorissen, S. H. M., Kamal, M., Bahniwal, R., Hector, A. J., Baker, S. K., Chabowski, A., Phillips, S. M. Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women.
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