Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise
Meade RD, Fujii N, McGarr GW, Alexander LM, Boulay P, Sigal RJ, Kenny GP
Journal of applied physiology (Bethesda, Md. : 1985) · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- CIHR
- Subvenciones
- Canadian Institutes of Health Research (286363)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-01-17 · J Appl Physiol (1985) · vol. 126 · número 4 · págs. 1129–1137
- Editorial
- American Physiological Society
- Citado
- 10 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Infrared Thermography in Medicine
- Palabras clave
- Arginase, Endocrinology, Internal medicine, Nitric oxide, Vasodilation, Chemistry, Arginine, Nitric oxide synthase, Forearm, Medicine, Surgery, Biochemistry
- MeSH
- forearm, skin, humans, nitric oxide, arginase, arginine, ng-nitroarginine methyl ester, body temperature, exercise, sweating, vasodilation, adult, middle aged, male, nitric oxide synthase, skin physiological phenomena, young adult
7 autores
- Robert D. Meade🇨🇦University of Ottawa
- Naoto Fujii🇯🇵🇨🇦University of Tsukuba; University of Ottawa
- Gregory W. McGarr🇨🇦University of Ottawa
- Lacy M. Alexander🇺🇸Pennsylvania State University
- Pierre Boulay🇨🇦Université de Sherbrooke
- Ronald J. Sigal🇨🇦University of Ottawa; University of Calgary; Ottawa Hospital; Ottawa Hospital Research Institute
- Glen Patrick Kenny🇨🇦 · autor de correspondenciaUniversity of Ottawa; Ottawa Hospital; Ottawa Hospital Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Age-related impairments in cutaneous vascular conductance (CVC) and sweat rate (SR) during exercise may result from increased arginase activity, which can attenuate endogenous nitric oxide (NO) production. We therefore evaluated whether arginase inhibition modulates these heat-loss responses in young (n = 9, 23 ± 3 yr) and older (n = 9, 66 ± 6 yr) men during two 30-min bouts of moderate-intensity cycling (Ex1 and Ex2) in the heat (35°C). CVC and SR were measured at forearm skin sites perfused with 1) lactated Ringer's (control), 2) NG-nitro-L-arginine methyl ester (L-NAME; NO synthase-inhibited), or 3) Nω-hydroxy-nor-arginine and S-(2-boronoethyl)-l-cysteine (Nor-NOHA + BEC; arginase-inhibited). In both groups, CVC was reduced at L-NAME relative to control and Nor-NOHA + BEC (both P P ≤ 0.05); however, no influence of treatment on SR in the older men was observed (P = 0.14). Based on these findings, we then evaluated responses in 7 older men (64 ± 7 yr) during passively induced elevations in esophageal temperature (∆Tes) equal to those in Ex1 (0.6°C) and Ex2 (0.8°C). L-NAME reduced CVC by 18 ± 20% CVCmax at a ∆Tes of 0.8°C (P = 0.03) compared with control, whereas Nor-NOHA + BEC augmented CVC by 20 ± 18% CVCmax, on average, throughout heating (both P ≤ 0.03). SR was not influenced by either treatment (P = 0.80) Thus, arginase inhibition does not modulate CVC or SR during exercise in the heat but, consistent with previous findings, does augment CVC in older men during passive heating. NEW & NOTEWORTHY In the current study, we demonstrate that local arginase inhibition does not influence forearm cutaneous vasodilatory and sweating responses in young or older men during exercise-heat stress. Consistent with previous findings, however, we observed augmented cutaneous blood flow with arginase inhibition during whole-body passive heat stress. Thus, arginase differentially affects cutaneous vasodilation depending on the mode of heat stress but does not influence sweating during exercise or passive heating.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.