Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome
Ostadmohammadi V, Jamilian M, Bahmani F, Asemi Z
Journal of ovarian research · 117 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Medical Research Development
- Sin clasificar
- NIMAD
- Subvenciones
- National Institute for Medical Research Development (97513)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-21 · J Ovarian Res · vol. 12 · número 1 · pág. 5
- Editorial
- BioMed Central
- Citado
- 169 citas · más que el 99% de estudios similares · 14.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ovarian function and disorders · Probiotics and Fermented Foods · Antioxidant Activity and Oxidative Stress
- Palabras clave
- polycystic ovary syndrome, vitamin D supplementation, probiotics, co-supplementation, mental health, depression, anxiety, testosterone, hirsutism, C-reactive protein, inflammatory markers, oxidative stress, malondialdehyde, glutathione, total antioxidant capacity, women's health, lifestyle intervention, quality of life, Beck Depression Inventory, General Health Questionnaire
- MeSH
- humans, polycystic ovary syndrome, hirsutism, inflammation, malondialdehyde, testosterone, vitamins, vitamin d, glutathione, c-reactive protein, double-blind method, mental health, oxidative stress, probiotics, adolescent, adult, female, young adult
4 autores
- Vahidreza Ostadmohammadi🇮🇷Kashan University of Medical Sciences
- Mehri Jamilian🇮🇷Arak University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Zatollah Asemi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).
Methods
This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 109 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks.
Results
Vitamin D and probiotic co-supplementation, compared with the placebo, significantly improved beck depression inventory [β (difference in the mean of outcomes measures between treatment groups) - 0.58; 95% CI, - 1.15, - 0.02; P = 0.04], general health questionnaire scores (β - 0.93; 95% CI, - 1.78, - 0.08; P = 0.03) and depression, anxiety and stress scale scores (β - 0.90; 95% CI, - 1.67, - 0.13; P = 0.02). Vitamin D and probiotic co-supplementation was associated with a significant reduction in total testosterone (β - 0.19 ng/mL; 95% CI, - 0.28, - 0.10; P < 0.001), hirsutism (β - 0.95; 95% CI, - 1.39, - 0.51; P < 0.001), high-sensitivity C-reactive protein (hs-CRP) (β - 0.67 mg/L; 95% CI, - 0.97, - 0.38; P < 0.001) and malondialdehyde (MDA) levels (β - 0.25 μmol/L; 95% CI, - 0.40, - 0.10; P = 0.001), and a significant increase in total antioxidant capacity (TAC) (β 82.81 mmol/L; 95% CI, 42.86, 122.75; P < 0.001) and total glutathione (GSH) levels (β 40.42 μmol/L; 95% CI, 4.69, 76.19; P = 0.02), compared with the placebo.
Conclusions
Overall, the co-administration of vitamin D and probiotic for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, plasma TAC, GSH and MDA levels.
Trial registration
This study was retrospectively registered in the Iranian website ( www.irct.ir ) for registration of clinical trials ( IRCT20170513033941N37 ).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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