25 Hydroxyvitamin D Levels are Negatively and Independently Associated with Fat Mass in a Cohort of Healthy Overweight and Obese Subjects
De Pergola G, Martino T, Zupo R, Caccavo D, Pecorella C, Paradiso S, Silvestris F, Triggiani V
Endocrine, metabolic & immune disorders drug targets · 34 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-22 · Endocr Metab Immune Disord Drug Targets · vol. 19 · número 6 · págs. 838–844
- Editorial
- Bentham Science Publishers
- Citado
- 49 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Cancer Risks and Factors
- Palabras clave
- Internal medicine, Medicine, Endocrinology, Overweight, Body mass index, Insulin resistance, Obesity, Blood pressure, Waist, Vitamin D and neurology, Cohort, Metabolic syndrome, Body fat percentage
- MeSH
- adipose tissue, humans, obesity, vitamin d, organ size, cohort studies, body composition, adolescent, adult, aged, middle aged, female, male, adiposity, overweight, young adult, obesity, metabolically benign
8 autores
- Giovanni De Pergola🇮🇹 · autor de correspondenciaUniversity of Bari Aldo Moro
- Tommaso Martino🇮🇹University of Bari Aldo Moro
- Roberta Zupo🇮🇹University of Bari Aldo Moro
- Domenico Caccavo🇮🇹University of Bari Aldo Moro
- Claudio Pecorella🇮🇹University of Bari Aldo Moro
- Silvia Paradiso🇮🇹University of Bari Aldo Moro
- Franco Silvestris🇮🇹University of Bari Aldo Moro
- Vincenzo Triggiani🇮🇹University of Bari Aldo Moro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obesity is associated with lower serum vitamin D (25(OH)D) levels through several mechanisms. The aim of the study was to examine the possibility of a negative association between fat mass and 25(OH)D levels in a cohort of otherwise healthy overweight and obese subjects, independently of age, sex, blood pressure levels and anthropometric and metabolic parameters.
Materials and methods
147 overweight and obese subjects (106 women and 41 men), aged between 18 and 69 years, were enrolled into the study. All of them did not show any clinically evident metabolic or chronic diseases (i.e. hypertension, diabetes mellitus, renal failure, etc.) and did not use any kind of drug. Serum fasting levels of 25(OH)D, insulin, glucose, uric acid and lipids (triglycerides, total, HDL and LDL cholesterol) were measured. The season in which the blood samples were collected was autumn. Insulin resistance was assessed by using the Homeostasis Model Assessment (HOMA-IR). Body composition parameters (Fat Mass [FM], Fat Free Mass [FFM], body cell mass [BCM], Total Body Water [TBW]) were measured by electrical Bioimpedance Analysis (BIA). Lastly, demographic, anthropometric and clinical parameters (age, Body Mass Index [BMI], Waist Circumference [WC], Systolic (SBP) and Diastolic (DBP) blood pressure) were also assessed.
Results
25(OH)D levels were significantly and negatively correlated with BMI (P <0.001), WC (P <0.01), DBP (P <0.05), insulin (P <0.001), HOMA-IR (P <0.01), triglycerides (P <0.01), and fat mass (P <0.001). A multivariate regression analysis was performed by considering 25(OH)D levels as the dependent variable and sex, waist circumference, fat mass, DBP, triglycerides, and insulin (or HOMAIR) as the independent ones, and 25(OH)D levels maintained a significant and independent relationship only with fat mass (negative) (P <0.01).
Conclusion
This study clearly shows that 25(OH)D circulating levels are progressively lower with the increase of fat mass, independently of sex, body fat distribution, blood pressure and insulin and metabolic parameters. These data strongly show that adipose tissue accumulation per se is absolutely the main factor responsible factor for lower 25(OH)D levels in obese subjects, possibly through sequestration of fat soluble 25(OH)D in fat mass.
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