Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial
Washburn RL, Cox JE, Muhlestein JB, May HT, Carlquist JF, Le VT, Anderson JL, Horne BD
Nutrients · 41 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Intermountain Research and Medical Foundation
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-23 · Nutrients · vol. 11 · número 2 · pág. 246
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 53 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Metabolomics and Mass Spectrometry Studies
- Palabras clave
- intermittent fasting, water-only fasting, trimethylamine N-oxide, metabolomics, plasma metabolites, coronary artery disease risk, diabetes risk, proline, tyrosine, galactitol, urea, refeeding
- MeSH
- humans, methylamines, fasting, pilot projects, adult, aged, middle aged, female, male, gas chromatography-mass spectrometry, metabolomics, metabolome
8 autores
- Rachel L. Washburn🇺🇸Texas Tech University; Texas Tech University Health Sciences Center
- James Eric Cox🇺🇸University of Utah
- Joseph Brent Muhlestein🇺🇸University of Utah; Intermountain Medical Center
- Heidi Thomas May🇺🇸Intermountain Medical Center
- John F. Carlquist🇺🇸University of Utah; Intermountain Medical Center
- Viet T. Le🇺🇸Intermountain Medical Center; Rocky Mountain University of Health Professions
- Jeffrey L. Anderson🇺🇸University of Utah; Intermountain Medical Center
- Benjamin Davies Horne🇺🇸 · autor de correspondenciaUniversity of Utah; Intermountain Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting (IF) has been connected with health benefits such as weight loss, lower risk of coronary artery disease (CAD) and diabetes, increased longevity, and improved quality of life. However, the mechanisms of these IF benefits in humans require further investigation. This study sought to elucidate some of these mechanisms through secondary analyses of the Fasting and ExprEssion of Longevity Genes during fOOD abstinence (FEELGOOD) trial, in which apparently healthy participants were randomized in a Latin square design to a 24-h water-only fast and a 24-h ad libitum fed day. Two pathways were investigated, with trimethylamine N-oxide (TMAO) levels measured due to their association with elevated risk of CAD, along with conductance of a broad panel of metabolic analytes. Measurements were made at baseline, at the end of the fasting day, and at the end of the fed day. A fasting mean of 14.3 ng in TMAO was found versus the baseline mean of 27.1 ng with p = 0.019, although TMAO levels returned to baseline on refeeding. Further, acute alterations in levels of proline, tyrosine, galactitol, and urea plasma levels were observed along with changes in 24 other metabolites during the fasting period. These acute changes reveal short-term mechanisms which, with consistent repeated episodes of IF, may lead to improved health and reduced risk of CAD and diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.