Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial
Thota RN, Acharya SH, Garg ML
Lipids in health and disease · 90 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-01-26 · Lipids Health Dis · vol. 18 · número 1 · pág. 31
- Editorial
- BioMed Central
- Citado
- 127 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Curcumin's Biomedical Applications · Natural Antidiabetic Agents Studies · Fatty Acid Research and Health
- Palabras clave
- curcumin, omega-3 polyunsaturated fatty acids, insulin resistance, insulin sensitivity, type 2 diabetes prevention, dyslipidemia, triglycerides, serum lipids, glycemic control, HbA1c, fasting blood glucose, HOMA-IR, dietary supplementation, beta-cell function, high-risk individuals
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, curcumin, insulin, blood glucose, lipids, fatty acids, omega-3, triglycerides, fasting, risk factors, dietary supplements, adult, aged, middle aged, female, male
3 autores
- Rohith N. Thota🇳🇿🇦🇺Riddet Institute; Massey University; University of Newcastle Australia
- Shamasunder Acharya🇦🇺John Hunter Hospital; Hunter New England Local Health District
- Manohar L. Garg🇳🇿🇦🇺 · autor de correspondenciaRiddet Institute; Massey University; University of Newcastle Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D.
Methods
This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcumin plus placebo matching for LCn-3PUFA (CC), or LCn-3PUFA plus placebo matching for curcumin (FO), or curcumin plus LCn-3PUFA (CC-FO) for twelve weeks. Primary outcome of the trial was glycaemic indices (HbA1C, fasting glucose and insulin). Insulin resistance and sensitivity is measured using homeostatic model assessment model.
Results
A total of sixty-four participants (PL, n = 16; CC, n = 15; FO, n = 17, CC-FO, n = 16) were included in the final analysis. Post-intervention, HbA1c and fasting glucose remained unchanged across all the groups. Insulin sensitivity was significantly improved in the CC supplemented group (32.7 ± 10.3%) compared to PL (P = 0.009). FO and CC-FO tended to improve insulin sensitivity by 14.6 ± 8.5% and 8.8 ± 7.7% respectively, but the difference did not reach significance. Triglyceride levels were further increased in the PL (26.9 ± 7.4%), however, CC and CC-FO supplementation reduced the triglycerides, FO resulted in the greatest reduction in triglycerides (- 16.4 ± 4.5%, P < 0.001).
Conclusion
Reduction in insulin resistance and triglycerides by curcumin and LCn-3PUFA appears to be attractive strategies for lowering the risk of developing T2D. However, this study failed to demonstrate complimentary benefits of curcumin and LCn-3PUFA on glycaemic control.
Trail registration
ACTRN12615000559516 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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