Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer
Zamaratskaia G, Mhd Omar NA, Brunius C, Hallmans G, Johansson JE, Andersson SO, Larsson A, Åman P, Landberg R
Clinical nutrition (Edinburgh, Scotland) · 14 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Higher Education, Malaysia
- Universidad u hospital
- Sveriges Lantbruksuniversitet
- Universidad u hospital
- Universiti Malaysia Pahang
- Gobierno
- Swedish Research Council – Medicine and FORMAS
- Gobierno
- Ministry of Higher Education Malaysia
- Universidad u hospital
- Swedish University of Agricultural Sciences
Según 6 financiadores declarados.
Publicación
- Publicado
- 2019-01-15 · Clin Nutr · vol. 39 · número 1 · págs. 159–165
- Editorial
- Elsevier BV
- Citado
- 28 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Inflammatory Biomarkers in Disease Prognosis
- Palabras clave
- whole grain rye, rye bran, prostate cancer, TNFR2, E-selectin, endostatin, endothelial function, inflammatory markers, cathepsin S, prostate-specific antigen, dietary intervention, low-grade prostate cancer
- MeSH
- humans, triticum, prostatic neoplasms, endostatins, e-selectin, receptors, tumor necrosis factor, type ii, diet, cross-over studies, aged, male, biomarkers, secale, whole grains
9 autores
- Galia Zamaratskaia🇸🇪Swedish University of Agricultural Sciences
- Nor Adila Mhd Omar🇸🇪 · autor de correspondenciaKarolinska Institutet
- Carl F. Brunius🇸🇪Swedish University of Agricultural Sciences; Chalmers University of Technology
- Göran Hallmans🇸🇪Umeå University
- Jan‐Erik Johansson🇸🇪Örebro University
- Sven-Olof Andersson🇸🇪Örebro University
- Anders Olof Larsson🇸🇪Uppsala University Hospital
- Per Åman🇸🇪Swedish University of Agricultural Sciences
- Rikard Landberg🇸🇪Karolinska Institutet; Chalmers University of Technology; Umeå University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Rye consumption has shown beneficial effects on prostate cancer tumors, as indicated by slower initial tumor growth in animal models and lowering of prostate-specific antigen (PSA) in humans. This study evaluated the effects of whole grain/bran rye consumption on low-grade inflammation and endothelial function biomarkers in men with prostate cancer.
Methods
Seventeen men with untreated, low-grade prostate cancer consumed 485 g rye whole grain and bran products (RP) per day or refined wheat products with added cellulose (WP) in a randomized crossover design. Fasting blood samples were taken before and after 2, 4, and 6 weeks of treatment.
Results
Concentrations of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). Cathepsin S concentration was positively correlated to TNF-R2 and endostatin concentrations across all occasions. Strong correlations were consistently found between intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and between interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1RA). No effect of intervention was found in 92 inflammation-related protein biomarkers measured in a proximity extension assay.
Conclusions
RP diet lowered TNF-R2, e-selectin, and endostatin, compared with WP in men with prostate cancer. These effects were accompanied by a reduction in PSA.
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