Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis
García-Serna AM, Morales E
Molecular psychiatry · 95 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministerio de Economía y Competitividad
- Gobierno
- Instituto de Salud Carlos III
- Gobierno
- Ministry of Economy and Competitiveness | Instituto de Salud Carlos III
- Subvenciones
- Ministerio de Economía y Competitividad (MS14/00046); Instituto de Salud Carlos III (MS14 /00046)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-01-29 · Mol Psychiatry · vol. 25 · número 10 · págs. 2468–2481
- Editorial
- Springer Nature
- Citado
- 119 citas · más que el 92% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Maternal Mental Health During Pregnancy and Postpartum · Birth, Development, and Health
- Palabras clave
- prenatal vitamin D, 25-hydroxyvitamin D, brain development, cognitive development, psychomotor development, language development, behavioral problems, attention deficit hyperactivity disorder, autistic traits, vitamin D deficiency, pregnancy
- MeSH
- humans, prenatal exposure delayed effects, vitamin d deficiency, vitamin d, cognition, attention deficit disorder with hyperactivity, autistic disorder, aging, pregnancy, infant, newborn, female, neurodevelopmental disorders
2 autores
- Azahara M. García‐Serna🇪🇸Instituto Murciano de Investigación Biosanitaria; Universidad de Murcia
- Eva Morales🇪🇸 · autor de correspondenciaInstituto Murciano de Investigación Biosanitaria; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad de Murcia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn blood at birth and neurodevelopmental outcomes, including cognition, psychomotor performance, language development, behavioral difficulties, attention deficit and hyperactivity disorder (ADHD), and autistic traits. PubMed, Web of Science and SCOPUS databases were systematically searched for epidemiologic studies published through May 2018 using keywords. Random-effects meta-analyses were conducted. Of 260 identified articles, 25 were included in the present review. Comparing the highest vs. the lowest category of prenatal 25(OH)D levels, the pooled beta coefficients were 0.95 (95% CI -0.03, 1.93; p = 0.05) for cognition, and 0.88 (95% CI -0.18, 1.93; p = 0.10) for psychomotor development. The pooled relative risk for ADHD was 0.72 (95% CI, 0.59, 0.89; p = 0.002), and the pooled odds ratio for autism-related traits was 0.42 (95% CI, 0.25, 0.71; p = 0.001). There was little evidence for protective effects of high prenatal 25(OH)D for language development and behavior difficulties. This meta-analysis provides supporting evidence that increased prenatal exposure to 25(OH)D levels is associated with improved cognitive development and reduced risk of ADHD and autism-related traits later in life. Associations represent a potentially high public health burden given the current prevalence of vitamin D deficiency and insufficiency among childbearing aging and pregnant women.
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