Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis
Anschau F, Webster J, Capra MEZ, de Azeredo da Silva ALF, Stein AT
Lasers in medical science · 36 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-02-07 · Lasers Med Sci · vol. 34 · número 6 · págs. 1053–1062
- Editorial
- Springer Science+Business Media
- Citado
- 69 citas · más que el 91% de estudios similares · 2.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, cancer therapy, chemotherapy, radiotherapy, mucositis severity, pediatric patients, adults
- MeSH
- humans, mouth neoplasms, stomatitis, treatment outcome, severity of illness index, risk factors, publication bias, adult, child, pain management, low-level light therapy
5 autores
- Fernando Anschau🇧🇷 · autor de correspondenciaHospital Nossa Senhora da Conceição; Pontifícia Universidade Católica do Rio Grande do Sul
- Jacqueline Webster🇧🇷Hospital Nossa Senhora da Conceição
- Marcelo Capra🇧🇷Hospital Nossa Senhora da Conceição
- André Luís Ferreira de Azeredo-da-Silva🇧🇷Hospital de Clínicas de Porto Alegre
- Aírton Tetelbom Stein🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre; Hospital Nossa Senhora da Conceição
Resumen
El texto original del estudio, en el idioma en que se publicó.
Review effectiveness of low-level laser therapy (LLLT) in the curative treatment of oral mucositis (OM) in patients receiving cancer therapy. A systematic review with meta-analysis was performed using Medline, Embase, and Cochrane Library databases according to PRISMA guidelines, to identify randomized controlled trials (RCT) on OM in patients during and/or after cancer therapy and in which the therapeutic approach was LLLT, with wavelengths between 632 and 970 nm. We considered grade of OM as a dichotomous variable (such as an improvement or not in severe OM on the seventh day of therapy), with the analysis of subgroups of adult patients or children and adolescents and as a continuous variable with determination of the time for the complete resolution and the subgroup analysis occurred with the strata of the samples by treatment only with chemotherapy or chemotherapy and radiotherapy. This paper's protocol was registered a priori at https://www.crd.york.ac.uk/PROSPERO . We found five RCT (total of 315 patients) with adequate methodology. LLLT was effective, presenting a 62% risk reduction of severe mucositis on the seventh day of evaluation (RR = 0.38 [95% CI, 0.19-0.75]). When we analyzed subgroups, RR was 0.28 (95% CI 0.17-0.46) in the adult studies and 0.90 (95% CI, 0.46-1.78) in the studies with children and adolescents. We demonstrated a mean reduction of 4.21 days in the time of complete resolution of OM (CI - 5.65 to - 2.76) in favor of LLLT. There is moderate evidence that LLLT is effective in resolving OM lesions in adult patients undergoing cancer therapy. LLLT demonstrates potential for decreasing the resolution time of OM lesions by approximately 4.21 days.
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