Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial
Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 38 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
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- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Johns Hopkins University
- Gobierno
- European Cooperation in Science and Technology
- Organización sin fines de lucro
- Fondation Leenaards
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Johns Hopkins Bloomberg School of Public Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Organización sin fines de lucro
- Swiss Society for Endocrinology-Diabetology
- Gobierno
- Swiss National Science Fund
- Gobierno
- NIEHS NIH HHS
- Gobierno
- 7th European Community Framework Programme
- Gobierno
- NCI NIH HHS
- Organización sin fines de lucro
- Leenaards Foundation
- Subvenciones
- National Institute of Environmental Health Sciences (P01 ES006052); National Cancer Institute (R01 CA190610); European Cooperation in Science and Technology (CA16112); National Cancer Institute (R35CA197222); National Institutes of Health (P01ES006052)
Según 13 financiadores declarados.
Publicación
- Publicado
- 2019-02-05 · Food Chem Toxicol · vol. 126 · págs. 1–6
- Editorial
- Elsevier BV
- Citado
- 49 citas · más que el 87% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Thyroid Disorders and Treatments · Selenium in Biological Systems
- Palabras clave
- sulforaphane, glucoraphanin, Nrf2, thyroid function, thyroid autoimmunity, thyroid-stimulating hormone, free thyroxine, thyroglobulin, chemoprevention, oxidative stress, cruciferous vegetables
- MeSH
- thyroid gland, humans, brassica, isothiocyanates, sulfoxides, thyrotropin, triiodothyronine, plant preparations, retrospective studies, autoimmunity, adult, aged, middle aged, female, male, nf-e2-related factor 2, young adult, fruit and vegetable juices
6 autores
- Dionysios V. Chartoumpekis🇺🇸University of Pittsburgh
- Panos G. Ziros🇨🇭Centre Hospitalier Universitaire Vaudois
- Jianguo Chen🇨🇳Qidong Liver Cancer Prevention Research
- John D. Groopman🇺🇸Johns Hopkins University
- Thomas W. Kensler🇺🇸University of Pittsburgh
- Gerasimos P. Sykiotis🇨🇭 · autor de correspondenciaCentre Hospitalier Universitaire Vaudois
Resumen
El texto original del estudio, en el idioma en que se publicó.
Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Previous studies addressing possible effects of sulforaphane-related compounds from natural product extracts on the thyroid were quite short and/or inconsistent. To investigate whether long-term exposure to a beverage enriched with sulforaphane and its precursor glucoraphanin may affect thyroid function, we analyzed biochemical measures of thyroid function and thyroid autoimmunity in 45 female participants in a randomized clinical trial at baseline and after 84 days of beverage administration. Serum levels of thyroid-stimulating hormone, free thyroxine and thyroglobulin were not affected by the treatment, and neither was the thyroid autoimmunity status of participants. These results provide evidence in favor of the safety of chemoprevention strategies that target the activation of Nrf2 to protect against environmental exposures and other oxidative stress-related pathologies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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