New-generation fish oil and olive oil lipid for prevention of oxidative damage in preterm infants: Single center clinical trial at university hospital in Turkey
Ozkan H, Koksal N, Dorum BA, Kocael F, Ozarda Y, Bozyigit C, Dogan P, Guney Varal I, Bagci O
Pediatrics international : official journal of the Japan Pediatric Society · 17 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2019-02-10 · Pediatr Int · vol. 61 · número 4 · págs. 388–392
- Editorial
- Wiley
- Citado
- 27 citas · más que el 85% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 19 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Infant Nutrition and Health · Fatty Acid Research and Health
- Palabras clave
- SMOFlipid, parenteral nutrition, preterm infants, oxidative stress, lipid peroxidation, total antioxidant capacity, cytokines, IL-10, bronchopulmonary dysplasia, fish oil
- MeSH
- humans, fat emulsions, intravenous, fish oils, cytokines, antioxidants, parenteral nutrition, prospective studies, double-blind method, lipid peroxidation, oxidative stress, infant, newborn, infant, premature, turkey, olive oil
9 autores
- Hilal Özkan🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Nilgün Köksal🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Bayram Ali̇ Dorum🇹🇷 · autor de correspondenciaBursa Uludağ Üni̇versi̇tesi̇
- Fatma Kocael🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Yeşim Özarda🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Cengiz Bozyigit🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Peli̇n Doğan🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- İpek Güney Varal🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
- Onur Bağcı🇹🇷Bursa Uludağ Üni̇versi̇tesi̇
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Parenteral nutrition (PN) has been widely used in preterm infants. The lipid solutions used for PN, however, are associated with oxidative stress and morbidity. The aim of this study was to compare the effectiveness of a new-generation lipid emulsion (SMOFLipid) and olive-oil based lipid emulsion for prevention of PN-associated oxidative damage.
Methods
Preterm infants < 32 weeks of gestational age were included in this prospective randomized study. All infants were randomized to SMOFlipid or olive-oil based lipid emulsion (ClinOleic). Lipid peroxidation products were evaluated in all infants. In addition, total antioxidant capacity (TAC), and both pro- and anti-inflammatory cytokines were studied at days 0, 7 and 14.
Results
A total of 89 infants (SMOFlipid, n = 42; ClinOleic, n = 47) were enrolled. TAC was higher in the SMOFlipid group compared with the ClinOleic group at all time points, and the difference on day 7 was statistically significant. Although the anti-inflammatory cytokine interleukin-10 was higher in the SMOFlipid group, this difference was not significant. Bronchopulmonary dysplasia (BPD) was lower in the SMOFlipid group (14.1%) than in the ClinOleic group (31.2%), but this finding was non-significant p > 0.05. The rate of severe BPD was significantly lower in the SMOFlipid group.
Conclusion
To our best of knowledge, this is the first study to suggest that SMOFlipid might decrease oxidative damage and oxidative-stress-associated morbidity compared with olive oil-based emulsion in preterm infants.
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