Effects of magnesium supplementation on carotid intima-media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial
Talari HR, Zakizade M, Soleimani A, Bahmani F, Ghaderi A, Mirhosseini N, Eslahi M, Babadi M, Mansournia MA, Asemi Z
The British journal of nutrition · 38 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kashan University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-02-11 · Br J Nutr · vol. 121 · número 7 · págs. 809–817
- Editorial
- Cambridge University Press
- Citado
- 46 citas · más que el 91% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Therapeutic Uses of Natural Elements
- Palabras clave
- Intima-media thickness, Placebo, Medicine, Double blind, Magnesium, Randomized controlled trial, Internal medicine, Diabetes mellitus, Placebo-controlled study, Cardiology, Endocrinology, Carotid arteries, Chemistry
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, malondialdehyde, cholesterol, insulin, blood glucose, c-reactive protein, antioxidants, treatment outcome, renal dialysis, double-blind method, dietary supplements, middle aged, female, male, metabolome, carotid intima-media thickness
10 autores
- Hamid Reza Talari🇮🇷Kashan University of Medical Sciences
- Mehrafrouz Zakizade🇮🇷Kashan University of Medical Sciences
- Alireza Soleimani🇮🇷Kashan University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Amir Ghaderi🇮🇷Kashan University of Medical Sciences
- Naghmeh Zahra Mirhosseini🇨🇦University of Saskatchewan
- Masoumeh Eslahi🇮🇷Kashan University of Medical Sciences
- Mahtab Babadi🇮🇷Kashan University of Medical Sciences
- Mohammad Alì Mansournia🇮🇷Tehran University of Medical Sciences
- Zatollah Asemi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=-9·42 pmol/l; 95% CI -14·94, -3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=-0·56; 95 % CI -0·89, -0·24; P=0·001) and HbA1c (β=-0·74 %; 95 % CI -1·10, -0·39; P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=-0·30 mmol/l; 95% CI -0·56, -0·04; P=0·02), LDL-cholesterol (β=-0·29 mmol/l; 95% CI -0·52, -0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.
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