The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis
Abuabat F, AlAlwan A, Masuadi E, Murad MH, Jahdali HA, Ferwana MS
NPJ primary care respiratory medicine · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-02-18 · NPJ Prim Care Respir Med · vol. 29 · número 1 · pág. 4
- Editorial
- Nature Portfolio
- Citado
- 16 citas · más que el 49% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Asthma and respiratory diseases · Respiratory and Cough-Related Research
- Palabras clave
- Medicine, Asthma, Placebo, Randomized controlled trial, Bronchodilator, Internal medicine, Meta-analysis, Quality of life (healthcare), Adverse effect, Alternative medicine, Pathology
- MeSH
- humans, asthma, magnesium, bronchodilator agents, administration, oral, dietary supplements
6 autores
- Faisal Abuabat🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Abdulaziz Alalwan🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Emad Masuadi🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Mohammad Hassan Murad🇺🇸Mayo Clinic
- Hamdan Al Jahdali🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center; National Guard Health Affairs
- Mazen Saleh Ferwana🇸🇦 · autor de correspondenciaKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center; National Guard Health Affairs
Resumen
El texto original del estudio, en el idioma en que se publicó.
Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. In addition to searching through Clinicaltrials.gov/ and references for oral magnesium supplement studies, we performed a database search in Medline, CINAHL, CENTRAL, and Embase. We contacted the authors of the included trials to ask for additional information. We included randomized controlled trials that compared oral magnesium supplements versus placebo, in addition to standard asthma treatment in mild-moderate asthmatic adults and children (older than 6 years). Two reviewers independently performed the study selection, data abstraction, and the assessment of the risk of bias. Eight trials at moderate risk of bias enrolling a total of 917 patients were included. Oral magnesium improved FEV1 at week 8 (5.69 (L/min); 95% CI: 1.92, 9.46; I2: 45%). There was no significant improvement in FEV1 at other follow up periods. There was no significant change in FVC, Methacholine challenge test, the frequency of bronchodilator use, or symptoms score. There were no data on mortality or quality of life. Oral magnesium supplements may lead to improvement in FEV1 that was only demonstrated at eight weeks; but no effect on any other outcome. Until future evidence emerges, oral magnesium cannot be recommended as adjuvants to standard treatment for mild to moderate asthmatic individuals.
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