Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults
Yang W, Ma Y, Liu Y, Smith-Warner SA, Simon TG, Chong DQ, Qi Q, Meyerhardt JA, Giovannucci EL, Chan AT, Zhang X
JAMA oncology · 71 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-02-21 · JAMA Oncol · vol. 5 · número 6 · pág. 879
- Editorial
- American Medical Association
- Citado
- 110 citas · más que el 99% de estudios similares · 9.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Liver Disease Diagnosis and Treatment
- Palabras clave
- Medicine, Whole grains, Refined grains, Bran, Hepatocellular carcinoma, Lower risk, Hazard ratio, Proportional hazards model, Dietary fiber, Cohort study, Cohort, Internal medicine, Physiology, Food science, Confidence interval, Biology
- MeSH
- humans, fruit, vegetables, carcinoma, hepatocellular, liver neoplasms, risk factors, cohort studies, follow-up studies, dietary fiber, adult, aged, aged, 80 and over, middle aged, united states, female, male, whole grains
11 autores
- Wanshui Yang🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Anhui Medical University
- Yanan Ma🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; China Medical University
- Yue Liu🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Beijing University of Chinese Medicine
- Stephanie A. Smith‐Warner🇺🇸Harvard University
- Tracey G. Simon🇺🇸Massachusetts General Hospital
- Dawn Qingqing Chong🇸🇬National Cancer Centre Singapore
- Qibin Qi🇺🇸Albert Einstein College of Medicine
- Jeffrey A. Meyerhardt🇺🇸Harvard University; Dana-Farber Cancer Institute
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Andrew Tan Chan🇺🇸Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
- Xuehong Zhang🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
Increased intake of whole grain and dietary fiber has been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for hepatocellular carcinoma (HCC). Therefore, we hypothesized that long-term intake of whole grains and dietary fiber may be associated with lower risk of HCC.
Objective
To assess the associations of whole grain and dietary fiber intake with the risk of HCC.
Design, setting, and participants
Cohort study of the intake of whole grains, their subcomponents (bran and germ), and dietary fiber (cereal, fruit, and vegetable) in 125 455 participants from 2 cohorts from the Nurses' Health Study and the Health Professionals Follow-up Study.
Exposures
Intake of whole grains, their subcomponents (bran and germ), and dietary fiber (cereal, fruit, and vegetable) were collected and updated almost every 4 years using validated food frequency questionnaires.
Main outcomes and measures
Multivariable hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards regression model after adjusting for most known HCC risk factors.
Results
After an average follow-up of 24.2 years, we identified 141 patients with HCC among 125 455 participants (77 241 women and 48 214 men (mean [SD] age, 63.4 [10.7] years). Increased whole grain intake was significantly associated with lower risk of HCC (the highest vs lowest tertile intake: HR, 0.63; 95% CI, 0.41-0.96; P = .04 for trend). A nonsignificant inverse HCC association was observed for total bran (HR, 0.70; 95% CI, 0.46-1.07; P = .11 for trend), but not for germ. Increased intake of cereal fiber (HR, 0.68; 95% CI, 0.45-1.03; P = .07 for trend), but not fruit or vegetable fiber, was associated with a nonsignificant reduced risk of HCC.
Conclusions and relevance
Increased intake of whole grains and possibly cereal fiber and bran could be associated with reduced risk of HCC among adults in the United States. Future studies that carefully consider hepatitis B and C virus infections are needed to replicate our findings, to examine these associations in other racial/ethnic or high-risk populations, and to elucidate the underlying mechanisms.
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