Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients
Ghaderi A, Banafshe HR, Mirhosseini N, Moradi M, Karimi MA, Mehrzad F, Bahmani F, Asemi Z
BMC psychiatry · 120 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Kashan University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-02-21 · BMC Psychiatry · vol. 19 · número 1 · pág. 77
- Editorial
- BioMed Central
- Citado
- 166 citas · más que el 99% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Schizophrenia research and treatment · Probiotics and Fermented Foods · Vitamin D Research Studies
- Palabras clave
- vitamin D, probiotics, chronic schizophrenia, combination supplementation, oxidative stress, insulin resistance, lipid metabolism, fasting blood glucose, C-reactive protein, total antioxidant capacity, malondialdehyde, PANSS scores, dietary supplementation, cholesterol, triglycerides, inflammation, antioxidant capacity, lipid profile, anxiety, quality of life
- MeSH
- humans, insulin resistance, malondialdehyde, vitamins, vitamin d, antioxidants, double-blind method, schizophrenia, dietary supplements, probiotics, adult, middle aged, iran, female, male
8 autores
- Amir Ghaderi🇮🇷Kashan University of Medical Sciences
- Hamid Reza Banafshe🇮🇷Kashan University of Medical Sciences
- Naghmeh Zahra Mirhosseini🇨🇦University of Saskatchewan
- Mohamad Moradi🇮🇷Kurdistan University of Medical Sciences
- Mohammad‐Amin Karimi🇮🇷Islamic Azad University, Tehran; Islamic Azad University, Science and Research Branch
- Fateme Mehrzad🇮🇷Kashan University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Zatollah Asemi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
This study determined the effects of a novel combination of vitamin D and probiotic on metabolic and clinical symptoms in chronic schizophrenia.
Methods
This trial was conducted among 60 patients with chronic schizophrenia to receive either 50,000 IU vitamin D3 every 2 weeks plus 8 × 109 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks.
Results
Vitamin D and probiotic co-supplementation was associated with a significant improvement in the general (- 3.1 ± 4.7 vs. + 0.3 ± 3.9, P = 0.004) and total PANSS scores (- 7.4 ± 8.7 vs. -1.9 ± 7.5, P = 0.01). Vitamin D and probiotic co-supplementation also significantly increased total antioxidant capacity (+ 51.1 ± 129.7 vs. -20.7 ± 53.3 mmol/L, P = 0.007), and significantly decreased malondialdehyde (- 0.3 ± 0.9 vs. + 0.2 ± 0.4 μmol/L, P = 0.01) and high sensitivity C-reactive protein levels (- 2.3 ± 3.0 vs. -0.3 ± 0.8 mg/L, P = 0.001) compared with the placebo. Moreover, taking vitamin D plus probiotic significantly reduced fasting plasma glucose (- 7.0 ± 9.9 vs. -0.2 ± 9.9 mg/dL, P = 0.01), insulin concentrations (- 2.7 ± 2.3 vs. + 0.4 ± 2.0 μIU/mL, P < 0.001), homeostasis model of assessment-estimated insulin resistance (- 0.8 ± 0.7 vs. + 0.1 ± 0.7, P < 0.001), triglycerides (- 7.8 ± 25.2 vs. + 10.1 ± 30.8 mg/dL, P = 0.01) and total cholesterol levels (- 4.9 ± 15.0 vs. + 5.9 ± 19.5 mg/dL, P = 0.04) and total-/HDL-cholesterol ratio (- 0.1 ± 0.6 vs. + 0.3 ± 0.8, P = 0.04).
Conclusion
Probiotic and vitamin D for 12 weeks to chronic schizophrenia had beneficial effects on the general and total PANSS score, and metabolic profiles.
Trial registration
This study was retrospectively registered in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT2017072333551N2). 07-31-2017 2.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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