Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials
Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci E
Annals of oncology : official journal of the European Society for Medical Oncology · 270 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation of Korea
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Research Foundation of Korea (NRF-2018R1C1B6008822); National Cancer Institute (R01CA138962); National Research Foundation of Korea (NRF-2018R1A4A1022589)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-02-20 · Ann Oncol · vol. 30 · número 5 · págs. 733–743
- Editorial
- Elsevier BV
- Citado
- 358 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Global Cancer Incidence and Screening
- Palabras clave
- vitamin D supplementation, cancer incidence, cancer mortality, 25-hydroxyvitamin D, circulating vitamin D levels, high-dose vitamin D, daily dosing, bolus dosing, randomized controlled trials, cancer prevention
- MeSH
- humans, neoplasms, vitamins, vitamin d, incidence, dietary supplements, united states, randomized controlled trials as topic
5 autores
- NaNa Keum🇺🇸🇰🇷 · autor de correspondenciaHarvard University; Dongguk University
- Dong Hoon Lee🇺🇸Harvard University
- Darren Charles Greenwood🇬🇧University of Leeds
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Edward L. Giovannucci🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous meta-analyses of randomized controlled trials (RCTs) of vitamin D supplementation and total cancer incidence and mortality found inconsistent results, and most included trials administered generally low doses of vitamin D (≤1100 IU/day). We updated the meta-analysis by incorporating recent RCTs that have tested higher doses of vitamin D supplements.
Materials and methods
PubMed and Embase were searched from the inception to November 2018. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a random-effects model.
Results
For total cancer incidence, 10 trials were included [6537 cases; 3-10 years of follow-up; 54-135 nmol/l of attained levels of circulating 25(OH) vitamin D [25(OH)D] in the intervention group]. The summary RR was 0.98 (95% CI, 0.93-1.03; P = 0.42; I2 = 0%). The results remained null across subgroups tested, including even when attained 25(OH)D levels exceeded 100 nmol/l (RR, 0.95; 95% CI, 0.83-1.09; P = 0.48; I2 = 26%). For total cancer mortality, five trials were included [1591 deaths; 3-10 years of follow-up; 54-135 nmol/l of attained levels of circulating 25(OH)D in the intervention group]. The summary RR was 0.87 (95% CI, 0.79-0.96; P = 0.005; I2 = 0%), which was largely attributable to interventions with daily dosing (as opposed to infrequent bolus dosing). No statistically significant heterogeneity was observed by attained levels of circulating 25(OH)D (Pheterogeneity = 0.83), with RR being 0.88 (95% CI, 0.78-0.98; P = 0.02; I2 = 0%) for ≤100 nmol/l and 0.85 (95% CI, 0.70-1.03; P = 0.11; I2 = 0%) for >100 nmol/l.
Conclusions
In an updated meta-analysis of RCTs, vitamin D supplementation significantly reduced total cancer mortality but did not reduce total cancer incidence.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.