Effect of caffeine on ovariectomy-induced osteoporosis in rats
Xu H, Liu T, Hu L, Li J, Gan C, Xu J, Chen F, Xiang Z, Wang X, Sheng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 40 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Major Scientific and Technological Special Project of Yunnan Province
- Gobierno
- Young Academic and Technological Leaders of Yunnan Province
- Universidad u hospital
- Academic Leaders of Yunnan Province
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-02-21 · Biomed Pharmacother · vol. 112 · pág. 108650
- Editorial
- Elsevier BV
- Citado
- 67 citas · más que el 91% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Bone health and treatments · Bone health and osteoporosis research · Cancer Risks and Factors
- Palabras clave
- Ovariectomized rat, Caffeine, Endocrinology, Internal medicine, Osteoporosis, Raloxifene, Alkaloid, Xanthine, Calcium, Medicine, Bone mineral, In vivo, Chemistry, Estrogen, Biology, Estrogen receptor, Biochemistry
- MeSH
- animals, humans, rats, rats, wistar, osteoporosis, postmenopausal, caffeine, phosphodiesterase inhibitors, organ size, ovariectomy, bone density, dose-response relationship, drug, female, lipid metabolism
10 autores
- Huanhuan Xu🇨🇳Yunnan Agricultural University; Tea Research Institute
- Titi Liu🇨🇳Yunnan Agricultural University; Tea Research Institute
- Lihong Hu🇨🇳Yunnan Agricultural University; Tea Research Institute
- Li Jin🇨🇳Yunnan Agricultural University; Tea Research Institute
- Chunxia Gan🇨🇳Yunnan Agricultural University; Tea Research Institute
- Jing Xu🇨🇳Yunnan Agricultural University; Tea Research Institute
- Fei Chen🇨🇳Yunnan Agricultural University; Tea Research Institute
- Zemin Xiang🇨🇳 · autor de correspondenciaYunnan Agricultural University; Tea Research Institute
- Xuanjun Wang🇨🇳 · autor de correspondenciaYunnan Agricultural University; Tea Research Institute
- Jun Sheng🇨🇳 · autor de correspondenciaYunnan Agricultural University; Tea Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine (1,3,7-trimethylxanthine) is a naturally occurring plant xanthine alkaloid present in many commonly consumed beverages worldwide, including tea, coffee, and cocoa. Although moderate caffeine intake is generally considered to exert positive effects on human health, its effect on bone metabolism remains controversial. The aim of this study was to systematically evaluate the pharmacological effect of long-term administration of caffeine on ovariectomy-induced postmenopausal osteoporosis in female rats. A sham operation or ovariectomy was performed to establish the ovariectomy rat model. The ovariectomized (OVX) rats were divided into five subgroups: OVX with vehicle (model), OVX with raloxifene hydrochloride (RLX, positive control; 4 mg/kg body weight/day), and OVX with low-, medium-, and high-dose caffeine (9.6, 19.2, and 38.4 mg/kg of body weight/day, respectively). Their corresponding treatments were administered intragastrically for 13 weeks. In-vivo studies showed that treatment with caffeine effectively improved the lipid profiles and increased the concentration of calcium in the serum of OVX rats. Medium- or high-dose treatment with caffeine significantly decreased the activities of alkaline and acid phosphatases in OVX rats. In addition, treatment with caffeine (at any dose) did not adversely affect organ weights, organ coefficients, femoral length, bone mineral density, biomechanical properties, or bone microarchitecture in OVX rats. Collectively, our study demonstrated that caffeine did not exert a damaging effect on the skeletal system of OVX rats.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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