Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial
Goncalves-Mendes N, Talvas J, Dualé C, Guttmann A, Corbin V, Marceau G, Sapin V, Brachet P, Evrard B, Laurichesse H, Vasson MP
Frontiers in immunology · 97 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Grupo de la industria
- Société Française de Nutrition Entérale et Parentérale
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-02-08 · Front Immunol · vol. 10 · pág. 65
- Editorial
- Frontiers Media
- Citado
- 143 citas · más que el 100% de estudios similares · 16.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Immune responses and vaccinations · Influenza Virus Research Studies
- Palabras clave
- vitamin D deficiency, influenza vaccine response, immunosenescence, older adults, vitamin D3, cathelicidin, plasma cytokines, TGF-beta, Th1/Th2 balance, 25-hydroxyvitamin D, innate immunity, cell-mediated immunity
- MeSH
- th1 cells, th2 cells, humans, orthomyxoviridae, vitamin d deficiency, transforming growth factor beta, vitamin d, influenza vaccines, vaccination, double-blind method, placebo effect, immune tolerance, dietary supplements, aged, female, male, influenza, human, th1-th2 balance
11 autores
- Nicolas Gonçalves-Mendes🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Jérémie Talvas🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Christian Dualé🇫🇷Inserm; Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Aline Guttmann🇫🇷Université Clermont Auvergne
- V. Corbin🇫🇷Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Geoffroy Marceau🇫🇷Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Vincent Sapin🇫🇷Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
- Patrick Brachet🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Bertrand Evrard🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Henri Laurichesse🇫🇷Université Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre Hospitalier Universitaire de Clermont-Ferrand
- Marie‐Paule Vasson🇫🇷 · autor de correspondenciaUniversité Clermont Auvergne; Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Centre Jean Perrin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Immunosenescence contributes to reduced vaccine response in elderly persons, and is worsened by deficiencies in nutrients such as Vitamin (Vit-D). The immune system is a well-known target of Vit-D, which can both potentiate the innate immune response and inhibit the adaptive system, and so modulate vaccination response. Objective: This randomized placebo-controlled double-blind trial investigated whether Vit-D supplementation in deficient elderly persons could improve influenza seroprotection and immune response. Design: Deficient volunteers (Vit-D serum n = 19), or a placebo (P, n = 19), over a 3 month period. Influenza vaccination was performed at the end of this period (V2), and the vaccine response was evaluated 28 days later (V3). At each visit, serum cathelicidin, immune response to vaccination, plasma cytokines, lymphocyte phenotyping, and phagocyte ROS production were assessed. Results: Levels of serum 25-(OH)D increased after supplementation (D group, V1 vs. V2: 20.7 ± 5.7 vs. 44.3 ± 8.6 ng/mL, p p = 0.040) and IL-6 (p = 0.046), and higher ones for TFGβ (p = 0.0028) were observed at V3. The Th1/Th2 ratio was lower in the D group at V2 (D: 0.12 ± 0.05 vs. P: 0.18 ± 0.05, p = 0.039). Conclusions: Vit-D supplementation promotes a higher TGFβ plasma level in response to influenza vaccination without improving antibody production. This supplementation seems to direct the lymphocyte polarization toward a tolerogenic immune response. A deeper characterization of metabolic and molecular pathways of these observations will aid in the understanding of Vit-D's effects on cell-mediated immunity in aging. This clinical trial was registered at clinicaltrials.gov as NCT01893385.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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