Antioxidative Effects and Mechanism Study of Bioactive Peptides from Defatted Walnut ( Juglans regia L.) Meal Hydrolysate
Sheng J, Yang X, Chen J, Peng T, Yin X, Liu W, Liang M, Wan J, Yang X
Journal of agricultural and food chemistry · 57 citas
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Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- China Postdoctoral Science Foundation
- Subvenciones
- National Natural Science Foundation of China (81703443); China Postdoctoral Science Foundation (2017M622461)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2019-02-28 · J Agric Food Chem · vol. 67 · número 12 · págs. 3305–3312
- Editorial
- American Chemical Society
- Citado
- 94 citas · más que el 94% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Protein Hydrolysis and Bioactive Peptides · Muscle metabolism and nutrition · Nuts composition and effects
- Palabras clave
- Juglans, Hydrolysate, Food science, Chemistry, Juglandaceae, Meal, Mechanism (biology), Traditional medicine, Biochemistry, Chromatography, Medicine, Hydrolysis
- MeSH
- neurons, cell line, humans, juglans, nuts, reactive oxygen species, peptides, plant proteins, protein hydrolysates, plant extracts, antioxidants, oxidative stress
9 autores
- Jianyong Sheng🇨🇳Huazhong University of Science and Technology
- Xiaoyu Yang🇨🇳Huazhong University of Science and Technology
- Jitang Chen🇨🇳Huazhong University of Science and Technology
- Tianhao Peng🇨🇳Huazhong University of Science and Technology
- Xiquan Yin🇨🇳Key Laboratory of Guangdong Province; Infinitus (China); Huazhong University of Science and Technology
- Wei Liu🇨🇳Huazhong University of Science and Technology
- Ming Liang🇨🇳 · autor de correspondenciaKey Laboratory of Guangdong Province; Infinitus (China); Huazhong University of Science and Technology
- Jiangling Wan🇨🇳 · autor de correspondenciaHuazhong University of Science and Technology
- Xiangliang Yang🇨🇳Huazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
The peptide components of defatted walnut ( Juglans regia L.) meal hydrolysate (DWMH) remain unclear, hindering the investigation of biological mechanisms and exploitation of bioactive peptides. The present study aims to identify the peptide composition of DWMH, followed by to evaluate in vitro antioxidant effects of selected peptides and investigate mechanisms of antioxidative effect. First, more than 1 000 peptides were identified by de novo sequencing in DWMH. Subsequently, a scoring method was established to select promising bioactive peptides by structure based screening. Eight brand new peptides were selected due to their highest scores in two different batches of DWMH. All of them showed potent in vitro antioxidant effects on H2O2-injured nerve cells. Four of them even possessed significantly stronger effects than DWMH, making the selected bioactive peptides useful for further research as new bioactive entities. Two mechanisms of hydroxyl radical scavenging and ROS reduction were involved in their antioxidative effects at different degrees. The results showed peptides possessing similar capacity of hydroxyl radical scavenging or ROS reduction may have significantly different in vitro antioxidative effects. Therefore, comprehensive consideration of different antioxidative mechanisms were suggested in selecting antioxidative peptides from DWMH.
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