Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption
Acevedo N, Frumento P, Harb H, Alashkar Alhamwe B, Johansson C, Eick L, Alm J, Renz H, Scheynius A, Potaczek DP
International journal of molecular sciences · 37 citas
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Publicación
- Publicado
- 2019-03-01 · Int J Mol Sci · vol. 20 · número 5 · pág. 1060
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 54 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
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- Entre el 10 % más citado de su campo
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- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Epigenetics and DNA Methylation · Birth, Development, and Health · Infant Nutrition and Health
- Palabras clave
- Offspring, Chromatin immunoprecipitation, Biology, Acetylation, Pregnancy, Epigenetics, Fish oil, Immune system, Histone, Internal medicine, Andrology, Endocrinology, Immunology, Gene, Genetics, Medicine, Gene expression, Fish <Actinopterygii>, Promoter, Fishery
- MeSH
- placenta, humans, protein kinase c, fish oils, t-box domain proteins, receptors, interleukin, histones, interleukin-13, protein processing, post-translational, acetylation, pregnancy, fish products, female, immunity, innate, maternal nutritional physiological phenomena, olive oil, lipopolysaccharide receptors, t-bet transcription factor, protein kinase c zeta
10 autores
- Nathalie Acevedo🇨🇴🇸🇪University of Cartagena; Karolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Paolo Frumento🇸🇪Karolinska Institutet
- Hani Harb🇺🇸🇩🇪Boston Children's Hospital; Harvard University; German Center for Lung Research; Universities of Giessen and Marburg Lung Center
- Bilal Alashkar Alhamwe🇩🇪🇸🇾German Center for Lung Research; Universities of Giessen and Marburg Lung Center; International University for Science and Technology
- Catharina Johansson🇸🇪Karolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Lisa Eick🇩🇪German Center for Lung Research; Universities of Giessen and Marburg Lung Center
- Johan S. Alm🇸🇪Karolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Harald E. Renz🇩🇪German Center for Lung Research; Universities of Giessen and Marburg Lung Center
- Annika Scheynius🇸🇪Science for Life Laboratory; Karolinska Institutet; Stockholm South General Hospital; Sachs' Children and Youth Hospital
- Daniel P. Potaczek🇵🇱🇩🇪 · autor de correspondenciaJohn Paul II Hospital; German Center for Lung Research; Universities of Giessen and Marburg Lung Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.
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