Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population
Song J, Jiang X, Cao Y, Juan J, Wu T, Hu Y
Journal of atherosclerosis and thrombosis · 9 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81573226); National Natural Science Foundation of China (81102177); National Natural Science Foundation of China (81172744); National Natural Science Foundation of China (81230066)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-02-28 · J Atheroscler Thromb · vol. 26 · número 9 · págs. 835–845
- Editorial
- Japan Atherosclerosis Society
- Citado
- 12 citas · más que el 86% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC-SA
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health · Fatty Acid Research and Health
- Palabras clave
- Medicine, Odds ratio, ABCA1, Confidence interval, Stroke (engine), Logistic regression, Internal medicine, Cardiology, Population, Cholesterol, Biology, Genetics, Gene, Environmental health
- MeSH
- humans, brain ischemia, carotid artery diseases, prognosis, diet, case-control studies, follow-up studies, eggs, middle aged, female, male, stroke, atp binding cassette transporter 1, asian people
6 autores
- Jing Song🇨🇳Peking University
- Xia Jiang🇸🇪Karolinska Institutet
- Yaying Cao🇨🇳Peking University
- Juan Juan🇨🇳Peking University; Peking University First Hospital
- Tao Wu🇨🇳Peking University
- Yonghua Hu🇨🇳Peking University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
ATP-binding cassette A1 (ABCA1) plays an important role in reducing the risk of stroke. Egg is the major source of dietary cholesterol and is known to be associated with the risk of stroke and atherosclerosis. We aimed to assess the effects of interaction between an ABCA1 variant (rs2066715) and egg consumption on the risk of ischemic stroke (IS), carotid plaque, and carotid-intima media thickness (CIMT) in the Chinese population.
Methods
In total, 5869 subjects (including 1213 IS cases) across 1128 families were enrolled and divided into two groups based on the median egg consumption (4 eggs per week). In the analyses for the presence of carotid plaque and CIMT, 3171 out of 4656 IS-free controls without self-reported history of coronary heart disease and lipid-lowering medications were included. Multilevel logistic regression models were used to model the genetic association of rs2066715 with the risk of IS, and mixed-effect linear regression for the genetic association of rs2066715 with carotid plaque, and CIMT. The gene-by-egg cross-product term was included in the regression model for interaction analysis.
Results
We found that rs2066715 was associated with the increased risk of carotid plaque among those who consumed ＜4 eggs per week after adjustment (odds ratio [95% confidence interval]: 1.61 [1.08, 2.39], P =0.019). A significant effect of interaction between rs2066715 and egg consumption on the risk of carotid plaque was identified (P =0.011).
Conclusion
rs2066715 was found to interact with egg consumption in modifying the risk of carotid plaque in the Chinese population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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