Financiado en parte por Arjuna Natural Ltd
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males
Lopresti AL, Drummond PD, Smith SJ
American journal of men's health · 61 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Arjuna Natural Ltd
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-03-01 · Am J Mens Health · vol. 13 · número 2 · pág. 1557988319835985
- Editorial
- SAGE Publishing
- Citado
- 101 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 86 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Complementary and Alternative Medicine Studies
- Palabras clave
- Withania somnifera, Vitality, Crossover study, Placebo, Medicine, Gerontology, Overweight, Traditional medicine, Internal medicine, Biology, Obesity, Alternative medicine, Genetics
- MeSH
- saliva, humans, fatigue, hormones, plant extracts, cross-over studies, double-blind method, adult, aged, middle aged, western australia, male, overweight, muscle strength, biomarkers, surveys and questionnaires
3 autores
- Adrian L. Lopresti🇦🇺 · autor de correspondenciaMurdoch University
- Peter D. Drummond🇦🇺Murdoch University
- Stephen James Smith🇦🇺Murdoch University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ashwagandha ( Withania somnifera) is a herb commonly used in Ayurvedic medicine to promote youthful vigor, enhance muscle strength and endurance, and improve overall health. In this 16-week, randomized, double-blind, placebo-controlled, crossover study, its effects on fatigue, vigor, and steroid hormones in aging men were investigated. Overweight men aged 40-70 years, with mild fatigue, were given a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks. Outcome measures included the Profile of Mood States, Short Form (POMS-SF), Aging Males' Symptoms (AMS) questionnaire, and salivary levels of DHEA-S, testosterone, cortisol, and estradiol. Fifty-seven participants were enrolled, with 50 people completing the first 8-week period of the trial and 43 completing all 16 weeks. Improvements in fatigue, vigor, and sexual and psychological well-being were reported over time, with no statistically significant between-group differences. Ashwagandha intake was associated with an 18% greater increase in DHEA-S ( p = .005) and 14.7% greater increase in testosterone ( p = .010) compared to the placebo. There were no significant between-group differences in cortisol and estradiol. In conclusion, the intake of a standardized ashwagandha extract (Shoden beads) for 8 weeks was associated with increased levels of DHEA-S and testosterone, although no significant between-group differences were found in cortisol, estradiol, fatigue, vigor, or sexual well-being. Further studies with larger sample sizes are required to substantiate the current findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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