The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study
Adawi M, Damiani G, Bragazzi NL, Bridgewood C, Pacifico A, Conic RRZ, Morrone A, Malagoli P, Pigatto PDM, Amital H, McGonagle D, Watad A
Nutrients · 66 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-03-12 · Nutrients · vol. 11 · número 3 · pág. 601
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 88 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Psoriasis: Treatment and Pathogenesis · Dietary Effects on Health · Dermatology and Skin Diseases
- Palabras clave
- Dactylitis, Enthesitis, Medicine, Psoriatic arthritis, Ankylosing spondylitis, Internal medicine, Psoriasis, Psoriasis Area and Severity Index, Body mass index, BASDAI, Gastroenterology, Arthritis, Immunology
- MeSH
- humans, arthritis, psoriatic, fasting, islam, adult, middle aged, female, male
12 autores
- Mohammad Adawi🇮🇱Bar-Ilan University
- Giovanni Battista Damiani🇮🇹🇺🇸Centro Studi GISED; University of Milan; IRCCS Ospedale Galeazzi - Sant'Ambrogio; Case Western Reserve University
- Nicola Luigi Bragazzi🇮🇹 · autor de correspondenciaUniversity of Genoa
- Charlie Bridgewood🇬🇧University of Leeds; Leeds Teaching Hospitals NHS Trust; NIHR Leeds Musculoskeletal Biomedical Research Unit
- Alessia Pacifico🇮🇹San Gallicano Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Rosalynn R.Z. Conic🇺🇸Case Western Reserve University
- Aldo Morrone🇮🇹San Gallicano Hospital; Istituti di Ricovero e Cura a Carattere Scientifico
- Piergiorgio Malagoli🇮🇹IRCCS Policlinico San Donato
- Paolo Daniele Maria Pigatto🇮🇹University of Milan; IRCCS Ospedale Galeazzi - Sant'Ambrogio
- Howard Amital🇮🇱Tel Aviv University; Sheba Medical Center
- Dennis McGonagle🇬🇧University of Leeds; Leeds Teaching Hospitals NHS Trust; NIHR Leeds Musculoskeletal Biomedical Research Unit
- Abdulla Ebrahem Watad🇬🇧🇮🇱 · autor de correspondenciaUniversity of Leeds; Tel Aviv University; Leeds Teaching Hospitals NHS Trust; Sheba Medical Center; NIHR Leeds Musculoskeletal Biomedical Research Unit
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent circadian fasting, namely Ramadan, is a common worldwide practice. Such fasting has a positive impact on psoriasis, but no data exist on its role in psoriatic arthritis (PsA)-a disease that is clearly linked to body mass index. We enrolled 37 patients (23 females and 14 males) with a mean age 43.32 ± 7.81 and they fasted for 17 h for one month in 2016. The baseline PsA characteristics were collected and 12 (32.4%) patients had peripheral arthritis, 13 (35.1%) had axial involvement, 24 (64.9%) had enthesitis, and 13 (35.1%) had dactylitis. Three patients (8.1%) were treated with methotrexate, 28 (75.7%) with TNF-α blockers, and 6 (16.2%) with IL-17 blockers. After a month of intermittent fasting, C-reactive protein (CRP) levels decreased from 14.08 ± 4.65 to 12.16 ± 4.46 (p p = 0.0078), Psoriasis Area Severity Index (PASI) decreased from 7.46 ± 2.43 to 5.86 ± 2.37 (p p p p = 0.0001). Fasting was found to be a predictor of a decrease in PsA disease activity scores (DAPSA, BASDAI, LEI, DSS) even after adjustment for weight loss. IL-17 therapy was found to be an independent predictor of decreases in LEI after fasting. These preliminary data may support the use of chronomedicine in the context of rheumatic diseases, namely PsA. Further studies are needed to support our findings.
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