Financiado en parte por Almond Board of California
Effects of almond consumption on metabolic function and liver fat in overweight and obese adults with elevated fasting blood glucose: A randomised controlled trial
Bowen J, Luscombe-Marsh ND, Stonehouse W, Tran C, Rogers GB, Johnson N, Thompson CH, Brinkworth GD
Clinical nutrition ESPEN · 35 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-01-11 · Clin Nutr ESPEN · vol. 30 · págs. 10–18
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 96% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Diet, Metabolism, and Disease · Nutritional Studies and Diet
- Palabras clave
- almond consumption, glycemic control, liver fat, overweight, obesity, fasting blood glucose, HbA1c, glycemic variability, adiposity, systemic inflammation, cardiometabolic health, TC/HDL-C ratio, sex differences, isocaloric diet
- MeSH
- liver, humans, diabetes mellitus, type 2, obesity, morbid, blood glucose, fatty acids, alpha-tocopherol, treatment outcome, diet, fat-restricted, adult, aged, middle aged, female, male, overweight, young adult, prunus dulcis
8 autores
- Jane Bowen🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Natalie D. Luscombe‐Marsh🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Welma Stonehouse🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Cuong Duy Tran🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Geraint B. Rogers🇦🇺South Australian Health and Medical Research Institute
- Nathan Anthony Johnson🇦🇺The University of Sydney
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Grant David Brinkworth🇦🇺 · autor de correspondenciaCommonwealth Scientific and Industrial Research Organisation; CSIRO Health and Biosecurity
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Almonds are a rich source of bioactive components. This study examined the effects of daily almond consumption on glycaemic regulation, liver fat concentration and function, adiposity, systemic inflammation and cardiometabolic health.
Methods
76 adults with elevated risk of type 2 diabetes (T2D) or T2D (age: 60.7 ± 7.7 years, body mass index: 33.8 ± 5.6 kg/m2) were randomly assigned to daily consumption of either 2 servings of almonds (AS:56 g/day) or an isocaloric, higher carbohydrate biscuit snack (BS) for 8 weeks. Glycosylated haemoglobin (HbA1c), glycaemic variability (GV), liver fat, serum aminotransferases, body weight and composition, markers of cardio-metabolic risk and systemic inflammation were assessed at baseline and week 8.
Results
No group differential effects were observed on HbA1c, GV, body weight and composition, liver fat and aminotransferases, cardio-metabolic health and inflammatory markers (all P > 0.05). For serum TC/HDL-C ratio a significant gender × treatment × time interaction occurred (P < 0.01), such that in women TC/HDL-C ratio was significantly reduced after AS compared to BS (-0.36 [0.26] mmol/L [n = 14] vs. -0.14 [0.32] mmol/L [n = 17]; P = 0.05), but not in men (P = 0.52).
Conclusions
Compared to BS, AS consumed between meals did not substantially alter glycaemic regulation, liver fat or function, adiposity, and metabolic health and inflammatory markers. Serum TC/HDL-C ratio improved in women, but not in men with AS; but as this sub-analysis was not defined a priori the results should be interpreted with caution. Further research should examine the longer-term health effects of regular almond consumption and differential gender responses.
Clinical trial registry number and website
Australia New Zealand Clinical Trial Registry: ACTRN12616000571471 (https://www.anzctr.org.au).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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