Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies
Hossain S, Beydoun MA, Beydoun HA, Chen X, Zonderman AB, Wood RJ
Clinical nutrition ESPEN · 98 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Gobierno
- Intramural Research Program of the NIH, National Institute on Aging
- Subvenciones
- National Institutes of Health (Z99 AG999999); National Institutes of Health (Z01 AG000513)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2019-01-09 · Clin Nutr ESPEN · vol. 30 · págs. 170–184
- Editorial
- Elsevier BV
- Citado
- 132 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Cancer Risks and Factors
- Palabras clave
- vitamin D, breast cancer, 25-hydroxyvitamin D, vitamin D deficiency, vitamin D intake, vitamin D supplementation, cancer risk
- MeSH
- humans, breast neoplasms, vitamin d deficiency, vitamins, vitamin d, odds ratio, nutritional status, dietary supplements, united states, female, observational studies as topic
6 autores
- Sharmin A Hossain🇺🇸National Institutes of Health; University of Massachusetts Amherst; National Institute on Aging
- May A. Beydoun🇺🇸 · autor de correspondenciaNational Institute on Aging
- Hind A. Beydoun🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Xiaoli Chen🇺🇸Massachusetts Department of Public Health
- Alan B. Zonderman🇺🇸National Institute on Aging
- Richard James Wood🇺🇸University of Massachusetts Amherst
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Breast cancer (BC) is the most common malignancy among women in the US. Vitamin D status and intakes are thought to be inversely associated with BC occurrence.
Objectives
In our systematic review and meta-analysis, we evaluated evidence linking serum 25(OH)D (both in serum and diet) with breast cancer (BC) occurrence.
Data sources and extraction
Only observational studies from databases such as PubMed and Cochrane (January 1st 2000 through March 15th, 2018) were included using PRISMA guidelines. Publication bias and consistency upon replication were assessed, while harmonizing risk ratios (RR, 95% CI) of BC, per fixed increment of 5 exposures [10 ng/mL of 25(OH)D; 100 IU/d for total/dietary vitamin D intakes; vitamin D deficiency; supplement use). RRs were pooled using random effect models.
Data analysis
Pooled findings from 22 studies suggested a net direct association between 25(OH)D deficiency and BC, with RRpooled = 1.91, 95% CI: 1.51-2.41, P pooled = 0.99, 95% CI: 0.97-1.00, P = 0.022, per 100 IU/d) and supplemental vitamin D (RRpooled = 0.97, 95% CI:0.95-1.00, P = 0.026) were inversely associated with BC. No evidence of publication bias was found; all 5 exposures of interest were consistent upon replication.
Conclusions
25(OH)D deficiency was directly related to BC while total vitamin D and supplemental vitamin D intakes had an inverse relationship with this outcome. Randomized clinical trials are warranted pending further evidence from primary meta-analyses of observational studies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.