Dietary nitrate intake is associated with muscle function in older women
Sim M, Lewis JR, Blekkenhorst LC, Bondonno CP, Devine A, Zhu K, Peeling P, Prince RL, Hodgson JM
Journal of cachexia, sarcopenia and muscle · 32 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Royal Perth Hospital Medical Research Foundation
- Gobierno
- Healthway
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (572604); National Health and Medical Research Council (254627, 303169 and 572604); National Health and Medical Research Council (303169); Healthway (572604); National Health and Medical Research Council (1107474); Healthway (254627); Healthway (303169); National Health and Medical Research Council (254627)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-03-24 · J Cachexia Sarcopenia Muscle · vol. 10 · número 3 · págs. 601–610
- Editorial
- Springer Science+Business Media
- Citado
- 36 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses · Muscle Physiology and Disorders
- Palabras clave
- Medicine, Nitrate, Logistic regression, Dietary Nitrate, Animal science, Grip strength, Dietary Reference Intake, Cross-sectional study, Internal medicine, Physiology, Nutrient, Ecology, Nitrite, Biology, Pathology
- MeSH
- humans, vegetables, nitrates, hand strength, nutrition assessment, cross-sectional studies, feeding behavior, aging, dietary supplements, aged, australia, female, independent living
9 autores
- Marc Sim🇦🇺 · autor de correspondenciaEdith Cowan University; Royal Perth Hospital
- Joshua Richard Lewis🇦🇺Edith Cowan University; The University of Sydney; Royal Perth Hospital; Children's Hospital at Westmead
- Lauren C. Blekkenhorst🇦🇺Edith Cowan University; Royal Perth Hospital
- Catherine P. Bondonno🇦🇺Edith Cowan University; Royal Perth Hospital
- Amanda Devine🇦🇺Edith Cowan University
- Kun Zhu🇦🇺Sir Charles Gairdner Hospital
- Peter Peeling🇦🇺The University of Western Australia
- Richard Lewis Prince🇦🇺Sir Charles Gairdner Hospital
- Jonathan M. Hodgson🇦🇺Edith Cowan University; Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In younger individuals, dietary nitrate supplementation has been shown to improve short-term vascular and muscle function. The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated. A cross-sectional study of relationships between dietary nitrate and measures of muscle function in older community-dwelling Australian women (n = 1420, ≥70 years) was undertaken.
Methods
Participants completed a semi-quantitative food frequency questionnaire assessing dietary intake over the previous year. Total nitrate from vegetables and non-vegetable sources was calculated from a validated instrument that quantified the nitrate content of food recorded within the food frequency questionnaire. Handgrip strength and timed-up-and-go (TUG) were assessed, representing muscle strength and physical function, respectively. Cut-points for weak grip strength (10.2 s) were selected due to their association with adverse outcomes. Linear and logistic regressions were used to examine the relationship between total nitrate intake and muscle function measures.
Results
Mean ± standard deviation (SD) total nitrate intake was 79.5 ± 31.2 mg/day, of which 84.5% came from vegetables. Across the unadjusted tertiles of nitrate intake (10.2 s) was 61.0% and 36.9%, respectively. Each SD higher nitrate intake (31.2 mg/day) was associated with lower odds for weak grip strength (OR 0.84, 95% CI 0.74-0.95, P = 0.005) and slow TUG (OR 0.86, 95% CI 0.76-0.98, P = 0.021). Compared with women in the lowest tertile of nitrate intake, women in the highest nitrate intake tertile had lower odds for weak grip strength (OR 0.65, 95% CI 0.49-0.87, Ptrend= 0.004) and slow TUG (OR 0.72, 95% CI 0.53-0.97, Ptrend = 0.044).
Conclusions
This investigation highlights potential benefits of nitrate-rich diets on muscle strength and physical function in a large cohort of older women. Considering poor muscle strength and physical function is associated with a range of adverse health outcomes such as falling, fractures, cardiovascular disease, and mortality, increasing dietary nitrate, especially though vegetable consumption may be an effective way to limit age-related declines in muscle function.
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