Effect of Creatine Supplementation on the Airways of Youth Elite Soccer Players
Simpson AJ, Horne S, Sharp P, Sharps R, Kippelen P
Medicine and science in sports and exercise · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Hull
Según 1 financiador declarado.
Publicación
- Publicado
- 2019-03-22 · Med Sci Sports Exerc · vol. 51 · número 8 · págs. 1582–1590
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 16 citas · más que el 69% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Chronic Obstructive Pulmonary Disease (COPD) Research
- Palabras clave
- Creatine, Exhaled nitric oxide, Placebo, Medicine, Athletes, Dose, Internal medicine, Physical therapy, Asthma, Spirometry
- MeSH
- lung, humans, hypersensitivity, immediate, inflammation, nitric oxide, creatine, breath tests, lung volume measurements, pulmonary ventilation, forced expiratory flow rates, double-blind method, soccer, dietary supplements, adolescent, male, performance-enhancing substances, physical conditioning, human, biomarkers
5 autores
- Andrew Simpson🇬🇧Brunel University of London
- Sara Horne🇬🇧Brunel University of London
- Peter C. Sharp🇬🇧Manchester City Football Club
- ROBERT SHARPS🇬🇧Manchester City Football Club
- Pascale Kippelen🇬🇧Brunel University of London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Owing to its well-established ergogenic potential, creatine is a highly popular food supplement in sports. As an oral supplement, creatine is considered safe and ethical. However, no data exist on the safety of creatine on lung function in athletes. The aim of this project was to evaluate the effects of a standard course of creatine on the airways of youth elite athletes.
Methods
Nineteen elite soccer players, 16-21 yr old, completed a stratified, randomized, double-blind, placebo-controlled, parallel-group trial. The creatine group (n = 9) ingested 0.3 g·kg⋅d of creatine monohydrate (CM) for 1 wk (loading phase) and 5 g·d for 7 wk (maintenance phase), and the placebo group (n = 10) received the same dosages of maltodextrin. Airway inflammation (assessed by exhaled nitric oxide, FENO) and airway responsiveness (to dry air hyperpnoea) were measured pre- and postsupplementation.
Results
Mild, unfavorable changes in FENO were noticed by trend over the supplementation period in the CM group only (P = 0.056 for interaction, η = 0.199), with a mean group change of 9 ± 13 ppb in the CM group versus -5 ± 16 ppb in the placebo group (P = 0.056, d = 0.695). Further, the maximum fall in forced expiratory volume in 1 s after dry air hyperpnoea was larger by trend postsupplementation in the CM group compared with the placebo group: 9.7% ± 7.5% vs 4.4% ± 1.4%, respectively (P = 0.070, d = 0.975). These adverse effects were more pronounced when atopic players only (n = 15) were considered.
Conclusion
On the basis of the observed trends and medium to large effect sizes, we cannot exclude that creatine supplementation has an adverse effect on the airways of elite athletes, particularly in those with allergic sensitization. Further safety profiling of the ergogenic food supplement is warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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