The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes
Jamilian M, Mirhosseini N, Eslahi M, Bahmani F, Shokrpour M, Chamani M, Asemi Z
BMC pregnancy and childbirth · 106 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Arak University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-03-29 · BMC Pregnancy Childbirth · vol. 19 · número 1 · pág. 107
- Editorial
- BioMed Central
- Citado
- 134 citas · más que el 99% de estudios similares · 15.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gestational Diabetes Research and Management · Trace Elements in Health · Magnesium in Health and Disease
- Palabras clave
- gestational diabetes mellitus, magnesium supplementation, zinc supplementation, calcium supplementation, vitamin D supplementation, inflammation, oxidative stress, C-reactive protein, malondialdehyde, total antioxidant capacity, pregnancy outcomes, macrosomia, newborn birth weight, prenatal nutrition, placental insufficiency, placental inflammation, placental oxidative stress
- MeSH
- humans, diabetes, gestational, inflammation, birth weight, calcium, magnesium, zinc, malondialdehyde, vitamin d, c-reactive protein, antioxidants, pregnancy outcome, treatment outcome, double-blind method, oxidative stress, pregnancy, dietary supplements, adult, infant, newborn, female, young adult, biomarkers
7 autores
- Mehri Jamilian🇮🇷Arak University of Medical Sciences
- Naghmeh Zahra Mirhosseini🇨🇦University of Saskatchewan
- Masoumeh Eslahi🇮🇷Kashan University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Maryam Shokrpour🇮🇷Arak University of Medical Sciences
- Maryam Chamani🇮🇷Iran University of Medical Sciences
- Zatollah Asemi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Diabetes is the most common medical condition in pregnant women and its complications affect both mother and fetus. The beneficial effects of vitamin D on gestational diabetes have been shown, though data on the effects of co-administration of vitamin D with other nutrients on pregnancy outcomes in gestational diabetes (GDM) are scarce. This study was aimed to determine the effects of magnesium-zinc-calcium-vitamin D co-supplementation on parameters of inflammation and oxidative stress, and pregnancy outcomes among women with GDM.
Methods
This randomized, double-blinded, placebo-controlled trial was conducted on 60 women with GDM not taking oral hypoglycemic agents. Patients were randomly assigned to take magnesium-zinc-calcium-vitamin D supplements (n = 30) or placebo (n = 30) for 6 weeks. Fasting blood samples were collected from participants at baseline and after the 6-week intervention to measure related biomarkers.
Results
Magnesium-zinc-calcium-vitamin D co-supplementation resulted in a significant reduction in serum high-sensitivity C-reactive protein (- 1.2 ± 3.5 vs. + 0.8 ± 2.0 mg/L, P = 0.01) and plasma malondialdehyde concentrations (- 0.3 ± 0.3 vs. + 0.3 ± 1.1 μmol/L, P = 0.003), as well as a significant increase in total antioxidant capacity levels (+ 38.2 ± 76.5 vs. -16.3 ± 93.5 mmol/L, P = 0.01), compared to placebo. We found a decreasing trend in newborns' weight (3089.8 ± 519.9 vs. 3346.3 ± 411.1 g, P = 0.05) and the rate of macrosomia (3.3% vs. 16.7%, P = 0.08) in the magnesium-zinc-calcium-vitamin D supplemented women.
Conclusions
Overall, the findings of this study have demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks to women with GDM may reduce biomarkers of inflammation and oxidative stress. This study was retrospectively registered on 25 April 2017 in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT201704225623N109).
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