Direct and indirect associations between dietary magnesium intake and breast cancer risk
Huang WQ, Long WQ, Mo XF, Zhang NQ, Luo H, Lin FY, Huang J, Zhang CX
Scientific reports · 28 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2019-04-08 · Sci Rep · vol. 9 · número 1 · pág. 5764
- Editorial
- Nature Portfolio
- Citado
- 41 citas · más que el 87% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Biomarkers in Disease Mechanisms · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Breast cancer, Odds ratio, Confidence interval, Case-control study, Internal medicine, Cancer, Logistic regression, C-reactive protein, Oncology, Gastroenterology, Inflammation
- MeSH
- humans, breast neoplasms, magnesium, c-reactive protein, interleukin-6, diet, adult, aged, middle aged, female, surveys and questionnaires
8 autores
- Wuqing Huang🇨🇳Sun Yat-sen University
- Weiqing Long🇨🇳Sun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
- Xiong‐Fei Mo🇨🇳Sun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
- Naiqi Zhang🇨🇳Sun Yat-sen University
- Hong L Luo🇨🇳Sun Yat-sen University
- Fang‐Yu Lin🇨🇳Sun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University
- Jing Huang🇨🇳Sun Yat-sen University
- Cai‐Xia Zhang🇨🇳 · autor de correspondenciaSun Yat-sen University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). This case-control study recruited 1050 case patients and 1229 control subjects. Inflammatory marker levels of 322 cases and 322 controls, randomly selected, were measured using ELISA, and data on dietary magnesium intake were collected using a food frequency questionnaire. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI), and path analysis was used to investigate the mediating effect. A higher magnesium intake was associated with a lower breast cancer risk (adjusted OR = 0.80, 95% CI = 0.65, 0.99). A positive association was found between the CRP level and breast cancer risk (adjusted OR = 1.43, 95% CI = 1.02-2.01). However, IL-6 was not found to be associated with breast cancer risk. Path analysis revealed that dietary magnesium affected breast cancer risk both directly and indirectly by influencing the CRP level. The results indicate that a direct negative association and an indirect association through influencing the CRP level were observed between dietary magnesium intake and breast cancer risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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